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Dr Samir Ayoub

Senior Lecturer in Pharmacology

Medicines Research Group

Pharmacology Programme and modules leadership, widening participation and promotion of pharmacology within further education community. Supervision of PhD and MSc students.

    Dr Ayoub is a Senior Lecturer in Pharmacology at the University of East London. He acquired his PhD training at the William Harvey Research Institute, London, which was followed by a post-doctoral post funded by the Leverhulme Trust as an Early Career Fellowship; during which time he was also a visiting scientist at Professor Daniel Simmons’s laboratory at the Brigham Young University, USA. Before joining the University of East London, Dr Ayoub worked as a Research Associate at the Institute of Heart and Lung, Imperial College London.



    Overview

    Most Recent Research

    Dr Ayoub’s research focus has been on the pharmacology of paracetamol and the non-steroidal anti-inflammatory drugs in inflammation, pain and thermoregulation and has been the first to provide substantial evidence on implicating cyclooxygenase variant  enzymes in mediating the thermoregulatory and analgesic actions of paracetamol. Dr Ayoub continues to be active in thisarea of research as well as in elucidating the role of interleukin-4 and cycloogenase-2 in the resolution of inflammation and macrophage  polarisation. In recent years, Dr Ayoub has been collaborating with colleagues at the University of East London in research aimed at elucidation of mechanisms involved in the development of addiction behaviours to alcohol in Drosophila.


    Collaborators

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    Research

    Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster. Front Physiol.
    2018;9:175. Published 2018 Mar 14. doi:10.3389/fphys.2018.00175
     

    Koyyada R, Latchooman N, Jonaitis J, Ayoub SS, Corcoran O, Casalotti SO. .

    First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid.J Pain Res. 2017;10:2703-2709. Published 2017 Nov 28.
    doi:10.2147/JPR.S143500

    Sharma CV, Long JH, Shah S, et al. .

    Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes. Eur J Pharmacol.
    2019;861:172609. doi:10.1016/j.ejphar.2019.172609

    Ayoub SS, Flower RJ..

    Pharmacological targeting of the GABAB receptor alters Drosophila's behavioural responses to alcohol. Addict Biol.
    2020;25(2):e12725. doi:10.1111/adb.12725
     

    Ranson DC, Ayoub SS, Corcoran O, Casalotti SO. .

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