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Dr Samir Ayoub

Senior Lecturer in Pharmacology

Medicines Research Group

Dr Samir Ayoub is a valued member of the Pharmacology programme and modules leadership, helping to widen participation and promotion of pharmacology within further education community. He is also a supervisor of PhD and MSc students.

    Dr Ayoub is a Senior Lecturer in Pharmacology at the University of East London. He acquired his PhD training at the William Harvey Research Institute, London, which was followed by a post-doctoral post funded by the Leverhulme Trust as an Early Career Fellowship; during which time he was also a visiting scientist at Professor Daniel Simmons’s laboratory at the Brigham Young University, USA. Before joining the University of East London, Dr Ayoub worked as a Research Associate at the Institute of Heart and Lung, Imperial College London.



    Overview

    Most Recent Research

    Dr Ayoub’s research focus has been on the pharmacology of paracetamol and the non-steroidal anti-inflammatory drugs in inflammation, pain and thermoregulation and has been the first to provide substantial evidence on implicating cyclooxygenase variant  enzymes in mediating the thermoregulatory and analgesic actions of paracetamol. Dr Ayoub continues to be active in thisarea of research as well as in elucidating the role of interleukin-4 and cycloogenase-2 in the resolution of inflammation and macrophage  polarisation. In recent years, Dr Ayoub has been collaborating with colleagues at the University of East London in research aimed at elucidation of mechanisms involved in the development of addiction behaviours to alcohol in Drosophila.


    Collaborators

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    Research

    Pharmacological targeting of the GABAB receptor alters Drosophila's behavioural responses to alcohol. Addict Biol.

    Ranson DC, Ayoub SS, Corcoran O, Casalotti SO. 2020; 25 (2):e12725. doi:10.1111/adb.12725.

    Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase -1 knockout mice is indicative of inhibition of cyclooxygenase -1 variant enzymes

    Ayoub SS, Flower RJ. 2019; 861:172609. doi:10.1016/j.ejphar.2019.172609. Eur J Pharmacol.

    Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster

    Koyyada R, Latchooman N, Jonaitis J, Ayoub SS, Corcoran O, Casalotti SO. 2018 Mar 14. doi:10.3389/fphys.2018.00175. Front Physiol.

    First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid

    Sharma CV, Long JH, Shah S, et al.. 2017 Nov 28. J Pain Res. 2017;10:2703-2709. doi:10.2147/JPR.S143500.

    Cyclooxygenases: Methods and Protocols, Methods in Molecular Biology Series  (www.springer.com/biomed/pharmaceutical+science/book/978-1-58829-953-6)

    Ayoub SS, Flower RJ and Seed MP. 2010. Springer. ISBN: 978-1-58829-953-6.

    Publications

    Funding

     QR funding by the University of East London to survey study on the perception of further education students on pharmacology. February 2019  £904.35 
     QR Fund by the University of East London. Mini-sabbatical (1 term) for teaching cover to spend time writing research papers. January 2018  £990
     Funding for Bioscience Research Conference by ReDS, July 2013  £1729.25
     Research and Knowledge Exchange Grant funded by School of Health, Sport and Bioscience, to fund research project aimed at further characterization of human macrophage cell line, February 2013  £7173.26
     Research Development fund by ReDS, Further characterization of the diclofenac induced cyclooxygenase-2 protein, March 2012  £5000
     Funding for PhD studentship by School of Health, Sport and Bioscience, “An investigation into the role of novel cyclooxygenase variant proteins in inflammation”, January 2012,  £63,912
     Funding by School of Health, Sport and Bioscience to present at the European Workshop on Lipid Mediators, Paris, 27-28th Sept 2012,  £600
     Cyclooxygenase variants in temperature regulation”. Early Career Fellowship. The Leverhulme Trust. Oct 06- Oct 08 *This award was announced in the Times Newspaper (Friday 15th September 2006, page 66)  £38,961

    Funding

    Scholarly activities

    - Member of the editorial board for Inflammopharmacology
    - Active Member of the British Pharmacological Society
    - Ambassador for the British Pharmacological Society



    Interests

    Portfolio

    Programmes:
    BSc (Hons) Pharmacology, BSc (Hons) Pharmaceutical Science, BSc (Hons) Medical Physiology

    Modules:
    Level 4: Professional Practice in Science
    Level 5: Fundamental & Experimental Pharmacology
    Level 5: Research and Career Development
    Level 5: Medication Management for nursing students
    Level 6: Neuropsychopharmacology (module Leader)
    Level 6: Neuropharmacology (module leader)
    Level 6: Systems Pharmacology and Advanced Therapeutics (module leader)
    Level 6: Toxicology
    Level 6: Research Project module
    Level 7: Advanced Techniques in Bioscience
    Level 7: MSc Research Project

    Teaching