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Dr Samir Ayoub

Senior Lecturer in Pharmacology

Medicines Research Group, Health, Sport and Bioscience

    Samir's recent research has focused on the identification of new therapeutic targets for inflammation


    Dr Samir Ayoub joined the School of Health and Bioscience as a lecturer in pharmacology in 2011. He graduated with a BSc in pharmacology from UEL in 2000, after which he joined the William Harvey Research Institute (WHRI), as a PhD student to investigate the role of novel cyclooxygenase variant enzymes during inflammation, pain and thermoregulation (2000-2004).

    As a post-doctorate scientist at WHRI Samir was awarded an Early Career Fellowship by the Leverhulme Trust (2006-2008), to further his work on novel cyclooxygenase enzymes (COX-3) in thermoregulation. As part of this fellowship Samir worked in the laboratory of Professor Daniel Simmons, Brigham Young University, Utah, USA in 2008.

    During his time at the WHRI, Samir worked on other projects which included identification of the mechanism of the regulatory function of annexin-A1 protein in acute pain and also in the development of allergic reactions. In 2010, Samir moved to Imperial College London, where he investigated the mechanism of pro-angiogenic action of mesenchymal stem cells.

    Samir is currently a Senior Lecturer in Pharmacology and the Programme Leader for Pharmacology and continues to lead research on the pharmacology of cyclooxygenase enzymes.

    Ambassador for the British Pharmacological Society

    Overview




    Samir is interested in the development of novel drug targets for the treatment of inflammatory, immune-mediated and painful conditions of the periphery and central nervous system including multiple sclerosis and rheumatoid arthritis.
    He continues to lead research on the mechanism of action of paracetamol and has recently been focussing on the use of paracetamol for new therapeutic purposes. Dr Ayoub is currently investigating the mechanisms of anti-inflammatory actions of certain medicinal herbs.

    Samir is interested in the development of novel drug targets for the treatment of inflammatory diseases. He is involved in the supervision of PhD students working on projects aimed at elucidating the mechanism of action of paracetamol. .

    Collaborators

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    Research

    Journal publications Christopher Bolton, Elizabeth E Wood and Samir S Ayoub (2013). N-methyl-D-aspartate (NMDA) receptor involvement in central nervous system prostaglandin production during the relapse phase of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE). Fundam Clin Pharmacol. 27(5):535-43

    Stefan Laufer, Greim, C., Luik, S., Ayoub, S.S. and Dehner, F (2008). Human whole blood assay for rapid and routine testing of non-steroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-2 activity. Inflammopharmacol. 16(4):155-161.

    Samir S. Ayoub, Wood, E.G., Bolton, C. (2007). The regulation of central nervous system prostaglandin levels in a chronic relapsing model of multiple sclerosis. Inflam Res Suppl.3 S358.

    Samir S. Ayoub, Paul R. Colville-Nash, Derek A. Willoughby and Renia M. Botting (2006). The involvement of a cyclooxygenase-1 gene derived protein in the antinociceptive action of paracetamol in mice. Eur. J. Pharmacol. 538, 57-65.

    Renia Botting, Samir S. Ayoub (2005). COX-3 and the mechanism of action of paracetamol/acetaminophen. Prostagl. Leukot. And Essent. Fatty Acids 72, 85-87.

    Samir S. Ayoub, Regina M. Botting, Sarita Goorha, Paul Colville-Nash, Derek Willoughby and Leslie R. Ballou (2004). Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxidesynthase-1 gene-derived protein. Proc. Natl. Acad. Sci. USA 101, 11165-11169.

    Book chapters Ayoub SS (2010). In vitro cyclooxygenase activity assay in tissue homogenates, in Cyclooxygenases: Methods and Protocols, Methods in Molecular Biology (Ed Ayoub SS, Flower RJ and Seed MP) pp117-120, Springer, New York.

    Ayoub SS and Polenzani L (2010). Prostanoid Extraction and Measurement, in Cyclooxygenases: Methods and Protocols, Methods in Molecular Biology (Ed Ayoub SS, Flower RJ and Seed MP) pp153-164, Springer, New York.

    Moore AR, Ayoub SS, Seed MP (2010). Cyclooxygenase enzymes and their products in the carragenaan-induced          pleurisy in rats, in Cyclooxygenases: Methods and Protocols, Methods in Molecular Biology (Ed Ayoub SS, Flower RJ and Seed MP) pp201-205, Springer, New York.

    Ayoub SS and Regina RM (2010). Iloprost-induced nociception: Determination of the site of anti-nociceptive action of cyclooxygenase inhibitors and the involvement of cyclooxygenase products in central mechanisms of nociception, in Cyclooxygenases: Methods and Protocols, Methods in Molecular Biology (Ed Ayoub SS, Flower RJ and Seed MP) pp207-215, Springer, New York.

    Ayoub SS and Flower RJ (2010). Non-steroidal anti-inflammatory drugs, in Fundamentals of Inflammation (Ed Serhan C, Ward P and Gilroy DW), pp 234-243, Cambridge Press

    Samir S Ayoub, Elizabeth E Wood, Sabih-ul Hassan and Christopher Bolton (2011). Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). Inflamma Res 60(10):919-28.

    Books Ayoub SS, Flower RJ and Seed MP (2010). Cyclooxygenases: Methods and Protocols, Methods in Molecular Biology Series, Springer. ISBN: 978-1-58829-953-6 ww.springer.com/biomed/pharmaceutical+science/book/978-1-58829-953-6).

    Samir S Ayoub, Gareth Pryce, Michael P Seed, Christopher Bolton, Roderick J Flower and David Baker (2011). Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404. Drug Metab Dispos. 39-1689-95

    Samir S Ayoub, Amrish Joshi, Mary Chol, Michael P Seed (2011). Inhibition of the diclofenac-induced cyclooxygenase-2 activity by paracetamol in cultured macrophages is not related to the intracellular lipid hydroperoxide tone. Fund. Clin. Pharmacol. 25:186-90

    Melanie J. Stables, Justine Newson, Samir S. Ayoub, Catherine Hyams, Derek W. Gilroy (2010). Cyclooxygenase inhibition primes the innate immune response in mouse and man and overcomes antibiotic resistance. Blood 116:2950-9.

    Samia Yazid, Samir S Ayoub, Egle Solito, Simon McArthur, Phuong Vo, Neil Dufton and Roderick Flower (2010). Anti allergic Drugs and the Annexin-A1 system. Pharmacol Reports 62:511-7.

    Samir S Ayoub, John C Hunter, Daniel L Simmons (2009). Answering the Burning Question of How TRPV1 Antagonists Cause Unwanted Hyperthermia. Pharmacol. Rev. 61:225-7.

    Samir S Ayoub, Regina M Botting, Amrish N Joshi, Michael P. Seed and Paul R Colville-Nash (2009). Activation of macrophage peroxisome proliferator-activated receptor-g by diclofenac results in the induction of cyclooxygenase-2 protein and the synthesis of anti-inflammatory cytokines. Molecul Cellul. Biochem. 327:101-110.

    Samir S. Ayoub, Samia Yazid and Roderick J. Flower (2008). Increased susceptibility of annexin-A1 null mice to nociceptive pain is indicative of a spinal antinociceptive role of annexin-A1. Br. J. Pharmacol. 154:1135-42.

    Publications


    Funding



    Interests

    Portfolio




    Samir was appointed the programme leader for pharmacology in 2012 and continues to successfully lead the pharmacology degree programme with students’ satisfaction steadily increasing year on year. He has also been instrumental in initiating summer placement opportunities in pharmacovigilance as well as research-based year 1 sandwich placements.  
    Samir introduced several new teaching methods to the pharmacology modules, which included the introduction of problem-based learning, discussion forums, research-lead teaching, external visits and guest speakers, which helped improve the student’s experience and also the pass rates, particularly to second year modules.
    PhD Supervision

    Project 1 “An investigation into the role of novel cyclooxygenase variant proteins in inflammation” – Director
    Project 2  “An investigation into the role of novel cyclooxygenase variant proteins thermoregulation”

    Programmes

    BSc (Hons) Pharmacology
    MSc Cellular and Molecular Pharmacology

    Modules

    Fundamental and Experimental Pharmacology (BS5004)
    Fundamentals of Pharmacology (BS5010)
    Neuropsychopharmacology (BS6008)
    Neuropharmacology (BS6013)
    Systems Pharmacology and Advanced Therapeutics (BS6011)
    Advanced Cellular Pharmacology and Physiology (BS7018)
    Psychopharmacology and Integrative Systems (BS7020)
    Molecular Pharmacology and Drug Development (BS7024)

    Teaching