Dr Hanieh Khalili
Lecturer in Pharmaceutics
Dr Khalili did her BSc and MSc in Chemistry and Analytical Chemistry in Iran. She then accomplished her PhD after completion of MSc in Drug Delivery at the UCL School of Pharmacy when she earned highest distinction on the MSc course. Her PhD was partially funded by PolyTherics for which the project was designed on PEGylation of antibody fragments (Fabs) using disulphide bridging method. Characterisation, conjugation and modification of several therapeutic antibodies (such as bevacizumab, trastuzumab, infliximab) were studied during her PhD studied. Dr Khalili did a postdoc research associate between UCL School of Pharmacy and Institute of Ophthalmology working with Profs Steve Brocchini and Sir Peng tee Khaw. The key focus of the post-doc was on development, and formulation of antibody mimetics such as bispecific antibodies and fusion proteins to modulate ocular healing after surgery and to develop dosage forms to inhibit inflammation, angiogenesis and fibrosis generally within the eye.
Antibody and protein formulations
Antibody modification and conjugations
In vitro inflammation assays
UCL Institute of Ophthalmology
UCL School of Pharmacy
A simple and rapid spectrophotometric method for the determination of ultra trace amounts of thallium (III) with 4-(4'-N,N-dimethylaminophenyl) urazole as a new reagent
Khalili, H., Rafiee, Z., Rezaei, B., Mallakpour, Sh.. 2005. Ann Chim. 897-903.
Antibody fragments: Prolonging circulation half-life special issue-antibody research
Herrington-Symes, A., Farys, M., Khalili, H., Brocchini, S.. 2013. Advances in Bioscience and Biotechnology . 689-698.
Invited book; Chemical and genetic modification
Farys, M. Ginn, C, Badescu, G., Peciak, K, Pawlisz, E., Khalili, H., Brocchini, S.. 2013. Wiley.
Comparative binding of disulfide-bridged PEG-Fabs
Khalili, H., Godwin, A., Choi, J., Lever, R., Brocchini, S.. 2012. Bioconjugate Chemistry. 2262-2277.
Khalili, H., Godwin, A., Choi, J., Lever, R., Khaw, P. T., Brocchini, S. . 2013. Bioconjugate Chemistry. 1870-1882.
Khalili, H., Khaw, P. T., Brocchini, S. . 2016. Biomaterials Science.
PEGylation and its impact on the design of new protein-based medicines
Ginn, C., Khalili, H., lever, R., Brocchini, S.. 2014. Future Med Chem. 1829-1846.
Storage stability of bevacizumab in polycarbonate and polypropylene syringes
H.Khalili, G. Sharma. A. Froome, P.T. Khaw, S. Brocchini. 2015. Nature-eye. 820-827.
Early Career Research Award, UEL, 2016-2017
Travel Grants, Biochemical Society, 2016
Drug delivery; ocular delivery
Formulation of antibody-based medicine (High concentration formulation, stability and aggregation studies)
Antibody mimetics; modification and conjugations
Bispecific antibodies; Fc-fusion protein
In vitro inflammation assays
Pharmaceutical Sciences, BSc and MSc