Dr Amrutha Chilumuri
Lecturer
MRG and Infection and Immunity, University of East London
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AE 4.42, Stratford Campus
School of Health Sport and Bioscience
University of East London
Water Lane
London
E15 4LZ - A.Chilumuri@uel.ac.uk +442082232719
Overview
Dr Chilumuri’s research interests are in neuroscience.
Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects. Compounds that specifically bind to Aβ are neuroprotective. The overexpression of genes such as catalase and KiSS-1 result in the production of proteins that bind to Aβ. The interaction of these proteins with Aβ was found to be protective against Aβ mediated toxicity in SH-SY5Y neuroblastoma cells. The neuroprotective protein sequence could be used to design peptides that can bind Aβ, which could be of therapeutic use in designing drugs for treating AD.
Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects. Compounds that specifically bind to Aβ are neuroprotective. The overexpression of genes such as catalase and KiSS-1 result in the production of proteins that bind to Aβ. The interaction of these proteins with Aβ was found to be protective against Aβ mediated toxicity in SH-SY5Y neuroblastoma cells. The neuroprotective protein sequence could be used to design peptides that can bind Aβ, which could be of therapeutic use in designing drugs for treating AD.
Collaborators
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test
Research
Publications
Funding
Neuroscience
Interests
Portfolio
Cellular Pathology/ Haematology