Dr Mohammed Tasab
School of Health, Sport and Bioscience
I hold the position of Laboratory Manager at UEL, following on from my previous post as Senior Scientific Officer. I have wide ranging experience from a variety of previous roles in academia and industry. This experience includes working in the pharmaceutical industry as a medical communications specialist, as the national engagement manager for UK PubMed Central [now European PubMed], Several posts as Postdoctoral Research Fellow at the University of Manchester, Research Assistant and Research Technician also at the University of Manchester and Research Technician at the University of Exeter.
My research interests include the assembly of structural proteins [esp. procollagen] within mammalian cells and the role of associated chaperone proteins. I have also carried out research into angiopoietins role in cell signalling and the mechanisms underlying bacterial persistence.
I have also contributed to the development of two commercial patents held by the University of Manchester including one for the design of novel collagens and another for regulation of persistence in E.coli
Procollagen Biosynthesis in mammalian cells
Tasab, M. and Bulleid, NJ. 2005. Protein Folding Handbook. 649-676.
Expression of rat neuronal nitric oxide synthase in Saccharomyces cerevisiae
Jones S, Tasab M, Ogden JE, Ballance DJ. 1996. J Biotechnol. 48: 37–41.
Identification of the molecular recognition sequence which determines the type-specific assembly of procollagen
Lees JF, Tasab M, Bulleid NJ. 1997. EMBO J. 16:908–16.
Hsp47: a molecular chaperone that interacts with and stabilizes correctly-folded procollagen
Tasab M, Batten MR and Bulleid NJ. 2000. EMBO J. 19:2204–11.
Sequence-specific recognition of collagen triple helices by the collagen-specific molecular chaperone HSP47
Tasab M, Jenkinson L, Bulleid NJ. 2002. J Biol Chem. 277:35007–12.
Molecular signals that determine type-specific assembly of procollagen chains
Lees JF, Tasab M, Bulleid NJ. 1996. Matrix Biol. 15:153–153.
Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis
Alfieri A, Watson JJ, Kammerer RA, Tasab M, Progias P, Reeves K, Brown NJ, Brookes ZL. 2012. Crit Care. 16(5):r182.
Protein disulphide isomerase family members show distinct substrate specificity
Jessop CE, Watkins RH, Simmons JJ, Tasab M and Bulleid NJ. 2009. J Cell Sci. 122:4287-95.
Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin
Alfieri A, Ong AC, Kammerer RA, Solanky T, Bate S, Tasab M, Brown NJ, Brookes ZL. 2014. Pharmacol Res. 80:43-51.