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Dr Joanne Tocher

Subject Head Biosciences

I graduated from the University of Edinburgh with a PhD in Chemistry. Before joining UEL I have undertaken research at Texas A&M University and University College London. I have also worked as a research project leader in British Gas. When I joined UEL I was initially funded by Cancer Research UK before gaining a University Award from the Wellcome Trust. My research has focused on redox processes in cancer development, protection and therapy. Over the years a diverse research interest has developed. A general description would be the redox activation of bio-reductive compounds used to target hypoxic cells in cancer therapy and in the treatment of anaerobic infections. Techniques include the use of electrochemical methods to generate short-lived redox intermediates and their interaction with biological molecules. The importance of biological relevance is a key feature of these studies. The range of compounds investigated has included nitro-aromatic derivatives, azo-dyes and novel transition metal compounds as therapeutic agents. A more recent interest is the design of new drugs and the implementation of natural products in cancer therapy



    Overview




    Redox processes in cancer development, protection and therapy.
    Over the years a diverse research interest has developed. A general description would be the redox activation of bio-reductive compounds used to target hypoxic cells in cancer therapy and in the treatment of anaerobic infections. Techniques include the use of electrochemical methods to generate short-lived redox intermediates and their interaction with biological molecules (primarily DNA) The importance of biological relevance is a key feature of these studies. The range of compounds investigated has included nitro-aromatic derivatives, benzotriazine N-oxides, azo-dyes and novel transition metals as therapeutic agents. A more recent interest is the implementation of natural products in cancer therapy.


    Collaborators

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    Research

    Journal publications A total of 36 publications in peer-reviewed Journals, including: M.A. Naylor, M.A. Stephens, J. Nolan, B. Sutton, J.H. Tocher, E.M. Fielden, G.E Adams and I.J Stratford, Anti-Cancer Drug Design, (1993), 8, 439.

    Invited reviews, overviews, monographs. Invited Review, General Pharmacology (1997) 28, 485

    Unpublished monographs and technical reports. Six technical reports produced for British Gas (restricted access).

    R.F Walmsley, J.H. Tocher and D.I Edwards, Int. J. Radiat. Biol., (1994), 65, 125.

    J.H. Tocher and D.I. Edwards, Int. J. Radiat. Oncol. Biol. Phys., (1994), 29, 307.

    J.H. Tocher and D.I Edwards, Biochem. Pharmacol., (1994), 48, 1089.

    J.H. Tocher and D.I Edwards, Free Rad. Res., (1994), 21, 277 .

    J.H. Tocher and D.I Edwards, Biochem. Pharmacol., (1995), 50, 1367.

    J.H. Tocher Free Radical Research, (2001), 35, 159-166.

    Contributions to Symposia Proceedings and Chapters in Books, Seventeen Symposia contributions; two book chapters: D.I. Edwards, J.H. Tocher, L.D. Dale, D.A. Widdick and N.S. Virk, in Selective Activation of Drugs by Redox Processes (1990) eds. G.E. Adams, A Breccia, E.M. Fielden and P. Wardman, Plenum Press, New York.

    J.H. Tocher, L.D. Dale and D.I. Edwards, in Selective Activation of Drugs by Redox processes (1990) eds. G.E. Adams, A, Breccia, E.M. Fielden and P. Wardman, Plenum Press, New York

    Publications


    Funding


    The development of novel ways of cancer treatment, specifically chemotherapy and new drug development.


    Interests

    Portfolio





    Individual Research Projects, (undergraduate and masters)
    Programmes related to Physiology and Drug Sciences

    Fellow of the Higher Education Academy

    Fellow of the Society of Biology

    British Association of Cancer Research

    Teaching