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Dr Charalampos (Babis) Rallis

Senior Lecturer in Biochemistry

Health, Sport and Bioscience

Charalampos (Babis) Rallis completed his PhD studies on Developmental Biology and Genetics at the National Institute for Medical Research (London, UK) under the supervision of Prof Malcolm Logan working on Vertebrate Limb Development and associated congenital syndromes. He then worked as a Postdoctoral Fellow with Prof David Ish-Horowicz, FRS at the Cancer Research UK (London, UK), studying vertebrate somite formation, axial stem cells and single-cell expression profiling. In 2009, Babis joined University College London as a research associate working with Prof Jurg Bahler towards a global perspective of cellular aging using pharmacological and genetic interventions and genome-wide approaches. Babis utilizes Synthetic and Systems Biology approaches as well as Genetic and Pharmacological interventions to study gene and protein networks that affect cellular and organismal growth, stress and lifespan. He runs a number of interdisciplinary projects from revealing the genetic basis of drug resistance to identifying pro-ageing and and anti-ageing genetic, epigenetic and environmental factors. His research outputs impact on the field of nutrition, growth regulation and cancer, bioprocessing and ageing.

    Ageing is associated with the gradual decline of physiological functions both at the cellular and organismal levels and is the major risk factor for multiple diseases, including cancer, diabetes, neurodegeneration and cardiovascular problems. The study of specific disease processes has long been a major focus of research. However, fundamental aspects of the ageing process are an essential part of the problem. A range of interventions that increase lifespan have an analogous effect on healthspan and importantly can ameliorate age-related pathologies. Exploring ways to slow or reverse ageing will impact, therefore, on multiple disease occurrences in the population and reduce the severity of disease symptoms. Such interventions target signalling pathways such as the target of rapamycin-TOR that affects lifespan from yeast to humans.



    Cellular Ageing
    Genetic and Environmental Factors affecting Lifespan
    Cellular Phenomics
    Translational Profiling
    Ageing Metabolome
    • Elected Member of the Royal Society of Biology (MRSB)
    • Member of the Biochemical Society
    • Member of the British Society for Developmental Biology
    • Member of the British Society for Cell Biology
    • Serving as reviewer/evaluator for numerous journals.
    • Reviewer and panel, member for funding bodies (BBSRC, MRC, ERC, EC)
    • Associate member of the F1000.
    • Honorary Lecturer at University College London
    • Associate Lecturer, Birkbeck College, University of London.

    Overview

    We focus on highly conserved nutrient-responsive pathways and transcription factors and utilise the fission yeast S.pombe as well as human and mouse tissue culture systems. We aim to uncover the workings of genetic and non-genetic factors in cellular ageing and disease that will enhance our knowledge for developing pharmacological biogerontology interventions. Such approaches will ultimately protect or delay from age-related pathologies and contribute to a healthier ageing population. We are particularly interested in the relationships between cellular growth and bioenergetics, macromolecular quality control mechanisms and stress as well as organelle communication systems during normal and pathological conditions.


    Collaborators

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    Research

    2017
    1.    Hoyos-Manchado R, Reyes-Martín F, Rallis C, Gamero-Estévez E, Rodríguez-Gómez P, Quintero-Blanco J, Bähler J, Jiménez J, Tallada VA (2017). RNA metabolism is the primary target of formamide in vivo. Sci Rep. Nov 21;7(1):15895. doi: 10.1038/s41598-017-16291-8.
    2.    Gonzalez S and Rallis C (2017). The TOR signalling pathway in Spatial and Temporal control of cell size. Front Cell Dev Biol. Jun 7;5:61. doi: 10.3389/fcell.2017.00061.
    3.    Rallis C, Townsend S and Bähler J (2017). Genetic interactions and functional analyses of gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Sci Rep  7:44257. doi:10.1038/srep44257.
    4.    Jeffares D, Jolly C, Hoti M, Speed D, Rallis C, Dessimoz C, Bähler J and Sedlazeck F (2016). Transient structural variations alter gene expression and quantitative traits in Schizosaccharomyces pombe. Nature Communications Jan 24;8:14061. doi: 10.1038/ncomms14061.

    2016
    5.       Malecki M, Bitton D, Rodríguez-López M, Rallis C, Calavia N and Bähler J (2016). Respiratory metabolism programs in fission yeast. Genome Biology, Nov 25;17(1):240.
    6.       Rallis C*, Bischof L*, Převorovský M*, Jeffares D, Arzhaeva Y and Bähler J (2016). Spotsizer: High-throughput quantitative analysis of microbial growth. Biotechniques Oct 1;61(4):191-201. *These authors contributed equally to this work.
    7.       Vishwanatha A, Rallis C, Subramanyaswamy S, D'Souza C, Bähler J, Schweingruber M. Identification of nuclear genes affecting 2-Deoxyglucose resistance (2016). FEMS Yeast Research. Sep;16(6). pii: fow061. doi: 10.1093/femsyr/fow061.
    8.       Brault A, Rallis C, Normant V, Garant JM, Bähler J, and Labbé S. Php4 is a key player for iron economy in meiotic and sporulating cells. Genes, Genomes, Genetics, Oct 13;6(10):3077-3095. doi: 10.1534/g3.116.031898.
    9.       Tomalin LE, Day AM, Underwood ZE, Smith GR, Pezze PD, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ, Shanley DP, Veal EA. Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2,with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed (2016). Free Radic Biol Med. 2016 Mar 1. pii: S0891-5849(16)00094-0. doi: 10.1016/j.freeradbiomed.2016.02.035.
    10.   Rallis C and Bähler J (2016). Cell-based and phenomics using fission yeast. Crit Rev Biochem Mol Biol. Nov 2:1-10. DOI:10.3109/10409238.2015.1103205. 

    2015                              
    11.   Bond ME, Brown R, Rallis C, Bähler J and Mole S (2015). A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Microbial Cell, 2,12:466 - 480; DOI:10.15698/ mic2015.12.241.
    12.   Bitton DA, Atkinson S, Rallis C, Smith GC, Ellis DA, Jeffares DC, Chen YYC, Malecki M, Codlin S, Lubas MS, Bachand F, Cotobal C, Marguerat S, Mata J, Jensen TH, Bähler J (2015). Skip and bin: pervasive alternative splicing is degraded by nuclear RNA surveillance in fission yeast. Genome Research, 25(6):884-96. doi: 10.1101/gr.185371.114.
    13.   Jeffares DC, Rallis C, Rieux A, Speed D, Převorovský M, Mourier T, Marsellach-Castellví FX, Iqbal Z, Lau W, Cheng T, Pracana R , Muelleder M, Lawson J, Chessel A, Bala S, Hellenthal G, O’Fallon B, Keane T, Simpson JT, Bischof L, Tomiczek B, Bitton D, Sideri T, Codlin S, Hellberg J, van Trigt L, Jeffery L, Atkinson S, Thodberg M, Febrer M, McLay K, Drou N, Brown W, Hayles J, Carazo Salas RE, Ralser M, Maniatis N, Balding DJ, Balloux F, Durbin D and Bähler J (2015). The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics 47(3):235-41. doi: 10.1038/ng.3215.

    2014
    14.   Sideri T, Rallis C, Bitton DA, Lages B, Du L-L and Bähler, J (2014). Sequence-based, systematic approach to identify factors affecting chronological lifespan in a competitive environment. Genes, Genomes, Genetics g3.114.014415. doi: 10.1534/g3.114.014415.
    15.   Sofola-Adesakin O, Castillo-Quan JI*, Rallis C*, Tain L*, Bjedov I, Rogers I, Martinez P, Khericha M, Cabechina M, Bähler J and Partridge L (2014). Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer’s disease. Frontiers in Aging Neuroscience, DOI: 10.3389/fnagi. 2014.00190.*These authors contributed equally to this work.
    16.   Bitton DA, Rallis C, Jeffares DC, Smith GC, Chen YYC, Codlin S, Marguerat S and Bähler J (2014). LaSSO, a strategy for genome-wide mapping of intronic lariats and branch-points using RNA-seq. Genome Research, DOI: 10.1101/gr. 166819.113.
    17.   Rallis C, Lopez-Maury L, Georgescu T, and Bähler J (2014). Inhibition of TORC1 signaling in fission yeast reveals genes involved in cellular aging and growth. Biology Open, doi: 10.1242/bio.20147245.

    2013
    18.   Rallis C and Bähler J (2013). Inhibition of TORC1 signalling and increased lifespan: gained in translation? Aging (Albany, NY).
    19.   Rallis C, Codlin S, and Bähler J (2013). TORC1 signalling inhibition by rapamycin and caffeine affect lifespan, global gene expression and cell proliferation of fission yeast. Aging Cell. 12(4):563-73. doi: 10.1111/acel.12080.

    2012
    20.   Pancaldi V, Sarac OS, Rallis C, McLean JR, Převorovský M, Gould K, Beyer A and Jürg Bähler (2012). Predicting the fission yeast interaction network. Genes, Genomes, Genetics 2:453-467; doi:10.1534/g3.111.001560.

    2011
    21.   Rallis C and Prevorovsky M (2011). Bright days for yeast research. Genome Biology, 12(5):305. doi: 10.1186/gb-2011-12-5-305.

    2010
    22.   Rallis C, Pinchin SM and David Ish-Horowicz (2010). Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis. Development 137 3591-3601 doi:10.1242/dev050070.
    23.   Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan G, Ish-Horowicz D, Walsh MP and Dedhar S (2010). Integrin-linked kinase is a bona fide protein kinase that regulates Glycogen Synthase kinase in vivo. PloS ONE 5(8): e12356.

    2009
    24.   Rallis C (2009). New tricks for an old favourite model. Genome Biology, 10:315.

    2008
    25.   Hanisch A, Vezzaro A and Rallis C (2008). Elucidating Developmental Gene Networks. Genome Biology, 9(6):310.

    2007
    26.   Bazigou E and Rallis C (2007). Cell Signalling and Cancer. Genome Biology, 8:310.
    27.   Rallis C (2007). Chickens get their place in the sun. Genome Biology, 8:306.

    2006
    28.   Rallis C (2006). Developmental Genomics Reaches New Heights. Genome Biology, 7(10):329.

    2005
    29.   Rallis C, Del Buono, J and Logan MPO (2005). Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo. Development. 132:1961-1970.

    2004
    30.   Rallis C (2004). T-box genes in limb development and disease. EThos, 409870, UIN: BLL01013171221.

    2003
    31.   Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Tabin CJ, Logan MPO (2003). Tbx5 is required for limb bud initiation and continued limb outgrowth and patterning. Development. 130:2741-51.

    2001
    32.   Rallis C, Stamataki D, Pontikakis S, Mankoo BS, Karagogeos D (2001). Isolation of the avian homologue of the homeobox gene Mox2 and analysis of its expression pattern in developing somites and limbs. Mech Dev. 104(1-2):121-4.

    Publications

    UEL Internal Grants

    BSCB/COB

    Funding

    Cellular Ageing
    Genetic and Environmental Factors affecting Lifespan
    Cellular Phenomics
    Translational Profiling
    Ageing Metabolome



    Interests

    Portfolio

     

    BS6003 Clinical Biochemistry Module Leader

    BS6001 Advances in Biotechnology and Biochemistry

    BS6009 Research Project

    BS5006 Molecular Genetics

    BS5001 Biology of Disease

    BS5003 Clinical Diagnostics

    BS4002 Cellular Biology

    BS7109 Health and Disease of Physiological Systems

     

    Internal moderator for International Partner Institution (AKMI)

     

    Teaching