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Professor Neville Punchard PhD, CBiol, FRSB, FIMLS, FIBMS, FHEA, MIoD

Dean of Health, Sport & Bioscience

Health, Sport and Bioscience

I have held the position of Dean of the School of Health, Sport and Bioscience since 2007, during which time the School has gone from strength to strength and is one of, if not, the most successful at UEL.




    A Dean of one, if not, the largest and most successful Schools at UEL, my role includes: providing strategic team leadership and management of academic, research, service and support staff in a large and diverse School that includes; bioscience and sport subjects amongst others, including health programmes; has increasing research, NSS and other outcomes. My School leads in the University in terms of: student experience, NSS, research income and financial profitability/viability. In addition to managing academic, administrative and technical staff I have also managed the University’s Director of Sport, the University’s Director of Olympic and Paralympic Operations and a community sports partnership hosted by the School. I am also actively involved in developing our international recruitment, e.g., Malaysia, Vietnam, China, India and other countries. The School now has programmes in physiotherapy, biomedical science and sports delivered in Greece for example.

    I am also the Chair the University’s Research Ethics Committee and sign off as sponsor all the University’s NHS and social care IRAS/NHS REC applications. I regularly chair various University staff and student disciplinary committees. In the past I have also chaired the University’s Sports and Physical Activity Development Group, the Stratford Estates Groups and a wide range of staff and student investigatory and complaint panels. I also chair the usual range of School exam and management committees. In total, I have chaired or, as appropriate, been a member of over 200 internal and external appointment panels, ranging from those for junior lecturing or support posts through to those for Professors/DScs, Deans/Directors and PVC/VCs.

    I also have contributed to the University through membership of other University committees and groups including; Research Review; RAE Review Group (2007-2008); Post-graduate Degree Committee; Union Consultation and Negotiation; Annual Planning Monitoring; Data Quality; Educational partnerships; Foundation degrees; External Partnerships and “improving the student experience”; Student bursaries; New Management Structures;. League Tables; Pandemic working group, and Regional Partnerships. As Dean I am a member of the usual University senior management and School committees, etc. I have also played a part in the University’s Estates Development through membership of the University’s: Estates Strategy working/ Implementation Groups; Stratford Development Group and New Build Projects Boards for major building projects, including a Library, Computing and Conference Centre and Sports Centre.

    I have maintained and developed external networking through direct contact with a wide range of organisations including: Professional bodies, such as the Society of Biology, Science Council and various Council of Deans; NHS bodies and local partners in Newham and Hackney; Newham Council, and a number of City of London Livery Societies. These include local School and Colleges, for example: I had a joint appointment funded by “Linking London” which has resulted in 6-8 progression agreements in the past; I have sponsored local college sports teams, and academic scholarships for local schools and Colleges. I have also developed good working relations with the NHS and sit on several London-wide NHS committees, i.e. London Higher, London Health Deans Group and have sat on the Central & East London Comprehensive Local Research Network. We were the original host to the Allied Health Professions Placement Management Agency for London for the last three years. During the period leading up to the games I also developed links with: London Development Agency (incl. Visit/Think London); Podium; British Paralympic Association; British Olympic Association; British Amateur Swimming Association; The London Organising Committee for the Olympic Games; Sport England through Proactive East and the local Community Sport Partnership Activity Network.

    I have many years’ experience in quality assurance, professional; accreditation, critical review development, delivery, enhancement and assessment of courses at undergraduate and postgraduate level. I regularly chair, or act in senior capacity as external member of, validation panels and exam boards, for University and partner institutions. I have also been involved in QAA style and professional accreditation subject or departmental reviews at my own and other institutions, and generally been involved in QA. I have been undergraduate external examiner for 2 Universities, Post-Graduate External examiner for 3 universities for taught programmes and for 3 universities for research programmes. I was also a member of the Advisory Panel for Biology Benchmarking Committee. Currently, I am a member of the following relevant University Committees; Quality and Standards Committee (QSC); Postgraduate Review Committee, and Academic board. I also regularly Chair School Exam boards and PhD Progress reviews. I have chaired various Faculty Research and postgraduate committees; led on QA training of post-graduate students and been a member of various University Research committees.

    Elected Fellow of the:

    - Society of Biology

    - Institute of Biomedical Science

    - Higher Education Academy

    Member of:

    - Institute of Directors,

    - Worshipful Company of Needlemakers

    i. Elected Fellow of the: Society of Biology; Royal Society of Medicine; Institute of Biomedical Science, and the Higher Education Academy.

    ii. Member of the following external committees:

    - Science Council’s Vocational Qualifications Committee. 

    - Society of Biology: London Branch Board; Professional Registration Committee, and regular Accreditation Panel Member.

    - International Association of Inflammation Societies (IAIS), inc.: Steering committee for the bi-annual meeting, "Inflammation' 95”, Inflammation 2001, and 2017, and IAIS committee.

    - British Inflammation Research Association (BIRAs): Academic Committee Member (from 1993); Secretary (1994 to ‘02); Newsletter Editor (from 1994-1998); Vice-Chair & Web Site Creator and Manager (from 2001); Institute of Biology Representative (from 1998).

    - London Higher Healthcare Education Group; London Deans for Health (’07+); NE London HIEC bid group (2009+); Central & East London Comprehensive Local Research Board (’08-‘11); LETB Transition Board and UCL Partners. 

    iii. Other: 

    - Judging at the National Science & Engineering Competition (NSEC) at The Big Bang, Birmingham

    - Previous member of research grants committees: Scholl Fund (local charity; 2007-2010) and St Thomas Special Trustees (‘89-92).

    - Previously: Parish Councillor (2000– 02) and Local Authority School Governor for two Schools.

    iv. Editorial roles: Editorial Board of; Journal of Inflammation; Journal of Occupational Medicine & Toxicology (2005+); Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs (1999-2006); International Drugs database (ID) Research Alerts (1997-8).v. Membership of Societies/Groups: Institute of Directors (‘11+); Society of Biology (‘12+); Council of Deans for Health (’07+); UK Council of Deans for Science (’07+); British Inflammatory Research Association (92+); Heads of University Centres for Biomedical Science (2002+); Heads of University Biological Sciences (2002+); Biochemical Society (1983-2014); British Society for Immunology (1983-2014); Committee on Publication Ethics (2004-2008). 

    vi. Grant Reviewer for: MRC; The Scholl Fund; Broad Medical Research Program, California, USA; Lottery Community Funds; Telethon Foundation (Italian); Anglian and Oxford Regional Health Authority; St Bartholomew’s Hospital Joint Research Board, The Special Trustees of St Thomas’ Hospital,. 

    vii. Journal Reviewer, for example for: Life Science; Journal of Inflammation; Marine drugs; Acta Biochimica Polonica; European Journal of Clinical Nutrition (Nature group); Inflammation Research; Lupus; Endocrinology and Metabolism; Current Drugs ID Alerts; British Journal of Pharmacology; Drugs, Gut; Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs; Nicotine & Tobacco Research.

    viii. Media Presentations: Chinese Radio and Independent TV interviews at London House and the Media Centre during the Beijing 2008 Games; Local radio interview on cell division and reproduction (Jan 24th, 2007). 1998 Luton & Dunstable Herald & Post: Interview on dangers of GM foods. Anglia Television Live News Broadcast: Expert comment on use of DNA fingerprinting to identify father of abandoned baby. 1999. Local radio 10-minute debate broadcast as part of Science Week in 1996.

    ix. Other presentations: To David Willets, Minister of State for Universities and Science, and the London Mayor’s Office, in support of Business and Innovation Centre in Dagenham, Nov. 2012, and Biomedical Science Careers (Connexions) conference, Univ. Hertfordshire, 2007).

    Overview

    i. Output: includes over 100; books, book chapters, peer-reviewed papers and conference presentations (separate list available on request).

    ii. Institutional & School Research Leadership: Chair of University Ethics Committee (since 2007). Previously; chair/member of several Faculty/School Research Committees; and, as Dean, proactively lead and direct research in the School.

    iii. Previously (at the University of Bedfordshire/Luton): member of University and Faculty Research committees; Lead role in Faculty Graduate School and organising residential training sessions and research days, research student recruitment and training; Chair of various faculty/ departmental research QA & review committees; managed and led several research groups in several Departments, (consisting of between 4-7 staff and 2-5 PhDs); research review and policy development at Departmental and Faculty level, and Initiated and developed a University-wide MSc by Research.

    iv. RAE: Lead role/ written, or made major input to 4 RAE/REF submissions, 2 at University of Bedfordshire & 2 at University of East London, one of the latter resulting in being placed 32nd out of 72 submissions in UoA 12 (Allied Health Professions and Studies), with an average score of 2.05 (above sector average), placing us in the top 3 Universities overall in London.

    v. Current research interests: commercial exploitation of research; undertaking biomedical research into cell signalling, free radicals and the immune system in inflammatory conditions, such as inflammatory bowel disease, and during cellular and physiological stress; investigating an in vitro model of granuloma formation. Previously I have been involved in other areas of biomedical science research through PhD supervision and other collaboration including inflammation of the skin, pregnancy and alcoholic liver diseases.

    vi. Previous funding Sources: South East Thames Regional Health authority; University of London; The Special Trustees of St Thomas' Hospital; National Association for Colitis and Crohn's Disease (NACC); Peel Medical Research Trust; Lambeth Endowed Charities; Astra Foundation; G.D. Searle; Paterson Charitable Trust; HEFCE (RAE); Biochemical Society and Yakult. While at St Thomas’ I was twice short-listed for Welcome Senior Fellowships and had an Medical Research Council application rated as a+.

    vii. International Meetings Organised & Chaired

    - Organising Committee for IAIS bi-annual meeting, Inflammation' 2017.

    - Chairing Session on: The Role of Inflammation in Exercise, International Convention on Science, Education & Medicine in Sport, Glasgow, July 2012

    -Chaired workshop on Inflammatory Bowel Diseases at Inflammation' 2001, Edinburgh, Sept. 2001. (Attendance of 500).

    -IAIS bi-annual meeting, Inflammation' 95, Brighton Sept. 1995. (Attendance of 800). Organised and chaired workshop on: Skin and Gastrointestinal Inflammation.

    viii. National Meetings Organised & Chaired:

    -Signalling in inflammatory & immune cells: cell surface to nucleus. Annual congress of the British Society for Immunology (BSI), Harrogate, 2004.

    -Nutrition and Inflammation. 9th Annual congress of the BSI, Harrogate, 2001.

    -The Endothelium and Inflammation. 7th Annual congress of the BSI joint with the British Society for Allergy and Clinical Immunology Harrogate, Nov. 30th- 3rd, 1999.

    -Chemokines (joint BIRAs session at BSI Annual Congress, Harrogate 1998).

    -Stroke and Neurodegenerative Diseases, St Thomas’ Hospital, Dec. 1st, 1995.

    -Cellular and Molecular Aspects of Inflammatory Bowel Disease, St Thomas’ Hospital, Nov., 1992

    ix. I have supervised over 14 research students to completion, 11 as 1st supervisor (Please note, these figures do not include 2-4 MD students, the supervision of which I was responsible for at St Thomas’ Hospital); I have acted as Examiner for a total of 7 research students and Chair of PhD Examinations for 2 or more. I have also: been a member of numerous MSc validation panels (University & Faculty level) for other Departments and Faculties; led on the introduction and validation of a new MSc by Research for the University of Luton; management of same programme within the same Faculty.


    Collaborators

    Research

    LIST OF PUBLICATIONS AND PRESENTATIONS

    BOOKS & BOOK CHAPTERS

    1. "Free radicals- A practical approach". Eds.: Neville A. Punchard & Frank Kelly. In the: 'The Practical Approach Series'. Series Eds.: D. Rickwood and B.D. Hames. IRL Press, Oxford. 1996.

    2. Introduction to Free Radicals; Chapter 1. In: Free Radicals- A practical approach. Eds.: Neville A. Punchard & Frank Kelly. In the: 'The Practical Approach Series'. Series Eds.: D. Rickwood and B.D. Hames IRL Press, Oxford. 1996. pp 1-8

    3. Production of Immortal Human Umbilical Endothelial Cells. Punchard, N.A., Watson, D.W. & Thompson, R.P.H. In: Culture of Immortalised Cells; Book 3 in the “Culture of Specialised Cells” series. Series Ed: R. Ian Freshney. Wiley-Liss. 1996. pp 203-258

    INVITED REVIEWS

    4. Inflammatory Bowel Disease & 5-aminosalicylic acid: ‘Viewpoint' article. British Inflammatory Research Association Newsletter, Dec 1990.

    5. Mechanism of action of 5-aminosalicylic acid. Punchard N.A., Greenfield, S.M. & Thompson R.P.H. Mediators of Inflammation 1992; 1, 151-165.

    6. Nod2 nuclei acid and Proteins (Expert Opinion; published anon). Expert Opinion on Therapeutic Patents, 2003, 13, 111-114

    PAPERS

    7. Prostaglandin production and zinc depletion in human pregnancy. Simmer, K., Punchard, N. A., Murphy, G. & Thompson, R.P.H. Paediatric Research, 1985; 19, 697-700.

    8. Umbilical arterial prostacyclin production and zinc content in relation to intrauterine growth retardation. Punchard, N.A., Simmer, K., Murphy, G. & Thompson, R.P.H. Progress in Lipid Research, 1986; 25, 431-2.

    9. Zinc and prostaglandin production in intrauterine growth retardation. Punchard N.A. PhD Thesis. University of London. 1988.

    10. Inhibition of red cell membrane lipid peroxidation by sulphasalazine and 5-aminosalicylic acid. Greenfield, S.M., Punchard, N.A. & Thompson, R.P.H. Gut, 1991; 32, 1156-1159.

    11. Red cell lipid peroxidation and antioxidant enzymes in iron deficiency. Acharya, J., Punchard, N.A., Taylor, J.A., Thompson R.P.H. & Pearson, T.C. European Journal of Haematology, 1991; 47, 287-291.

    12. The effects of sulphasalazine and its metabolites on prostaglandin production by human mononuclear cells. Punchard, N.A., Boswell, D.J., Greenfield, S.M. & Thompson R.P.H. Biochemical Pharmacology, 1992; 43, 2369-2376.

    13. The effects of 5-aminosalicylic acid and acetyl-5-aminosalicylic acid on lipid peroxidation in erythrocytes and prostaglandin production by mononuclear cells. Greenfield, S.M., Boswell, D., Punchard N.A. & Thompson R.P.H. Alimentary Pharmacology and Therapeutics 1992; 6, 671-683.

    14. A randomised controlled study of evening primrose oil and fish oil in ulcerative colitis. Greenfield, S.M., Green, A.T., Teare J.P., Jenkins, A.P., Punchard N.A., Ainley C.C., & Thompson R.P.H. Alimentary Pharmacology and Therapeutics 1993; 7, 159-166.

    15. Expression of adhesion molecules on circulating leucocytes in patients with inflammatory bowel disease. Greenfield, S.M., Hamblin A.H., Punchard N.A. & Thompson R.P.H. Clinical Science 1992; 83, 221-226.

    16. Inhibition of leukocyte adhesion molecule upregulation by tumour necrosis factor a: a novel mechanism of action of sulphasalazine. Greenfield, S.M., Hamblin A.H., Shakoor Z.S., Punchard N.A. & Thompson R.P.H. Gut 1993; 34, 252-256.

    17. Effect of Thyroidectomy and adrenalectomy upon liver glutathione and malonaldehyde in response to acute ethanol injection. Teare J.P., Punchard N.A., Greenfield S.M., Marway J.S. Preedy V.R., Peters T.J. & Thompson R.P.H. Free Radical Biology and Medicine 1993; 14; 655-660.

    18. The mode of action of the aminosalicylics in inflammatory bowel disease. Greenfield S.M., Punchard N.A., & Thompson R.P.H. Alimentary Pharmacology and Therapeutics 1993; 7, 369-383.

    19. An automated spectrophotometric method for determining oxidised and reduced glutathione. Teare J, Punchard, N.A., Powell J.J., Lumb P.J., Mitchell W.D. & Thompson R.P.H. Clin Chem 1993; 38, 686-689.

    20. Resistance of erythrocytes to lipid peroxidation in alcoholics. Punchard, N.A., Senturk, H, Teare J, & Thompson, R.P.H. Gut 1994 Gut 1994;35, 1753-1756.

    21. Lipid peroxidation in rats chronically fed ethanol. Teare J.P., Greenfield S.M., Watson D., Punchard N.A., Miller N. , Rice-Evans C.A. and Thompson R.P.H. Gut 1994 35, 1644-1647

    22. A trial of oral zinc supplementation in Psoriasis. Burrows N., Turnbull A.J., Punchard N.A., Thompson R.P.H. & Russell Jones, R. Cutis 1994; 24, 117-118

    23. Proliferative T-cell responses to human papillomavirus type 16 E5 are decreased amongst women with high-grade neoplasia. Gill, D., Bible, J., Biswas, C., Kell, B., Best, J.M., Punchard, N.A. & Cason, J. J. Virology 1998; 79, 1971-1976.

    24. Activation of NFkB in Crohn’s Disease. Ellis, R., Goodlad J.R. ,Limb, G.A., Powell, J.P., Thompson, R.P.H. & Punchard, N.A. Inflammation Research 1998; 47, 440-445.

    25. Inflammatory bowel diseases; something old, something new? (Editorial). Punchard N.A., Current Opinions in Anti- Inflammatory & Immunomodulatory Investigational Drugs 2000 2, 272-4.

    26. Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. Punchard, N.A., Mullins, J. G.Ll. Green, A.T. &.Thompson, R.P.H. Prostaglandins, Leukotrienes & Essential Fatty Acids 2000; 62, 27-33.

    27. Lipopolysaccharide and silica stimulated mononuclear cell prostaglandin production in ulcerative colitis. Punchard, N.A.. Cason, J., Mullins, J., Chander, C., & Thompson, R.P.H. Mediators of Inflammation 2000: 9, 189-191.

    28. Glucorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Kagoshima, M., Wilcke, T., Ito, K., Tsaprouni, L., Barnes, P.J., Punchard, N.A. & Adcock, I. European Journal of Pharmacology, 2001: 429, 327-34.

    29. Nod2 and Crohn's disease: the cause, or contributor to Crohn's disease? (Overview). Punchard N.A., Current Opinions in Anti- Inflammatory & Immunomodulatory Investigational Drugs 2001: 2, 1378-81

    30. Triamcinolone Acetonide and Dexamethasone suppress TNF-a-Induced histone H4 acetylation on lysine residues 8 & 12 in mononuclear cells. Tsaprouni, L., Ito, K., Punchard, N.A. & Adcock, I. Ann. N. Acad. Sci. 2002: 973, 1-4.

    31. Selective Binding of nucleotide probes by eosinophlilic cationic protein during in situ hybridisation. Ellis, R., Ashwood, P., Powell, J.P., Taylor, P.D., Poulson, R., Thompson, R.P.H & Punchard, N.A. The Histochemical Journal, 2002, 34, 153-160.

    32. Nod2 nucleic acid and Proteins (Invited Expert Opinion; published anon). Expert Opinion on Therapeutic Patents, 2003, 13, 111-114.

    33. Editorial: The Journal of Inflammation. Punchard, N.A. , Whelan, C.J., Adcock, I. Journal of Inflammation 2004, 1: 1.

    34. Report of resistance to the neonicotinoid insecticide imidacloprid in Trialeurodes vaporariorum (Hemiptera: Aleyrodidae). Gorman, K., Devine G., Bennison, J., Coussons, P. Punchard, N., & Denholm, I. Pest Management Science 200, 63: 555-8.

    35. Dietary Calcium Modulates Muco7,al Caspase Expression and Disease Activity in the DSS Model of Murine Colitis. Powell1, J.J., Pele1, L.C. Thoree1, V., Mustafa1, F., He1, S., Tsaprouni, L., Punchard, N.A., Thompson, R.P.H & Evans, S. M. Journal of Nutrition 2007, 137: 2475-80. 2007

    36. Suppression of LPS and TNFa-induced IL-8 expression by glucocorticoids involves changes in acetylation of the IL-8 promoter. Tsaprouni, L. Ito, K., Adcock, I., & Punchard, N.A. Clinical & experimental Immunology 2007; Clin Exp Immunol. 2007, 150: 151-7.

    37. The Role of JAK2 and PKB in LPS stimulated NF-kappaB activation in RAW 264.7 cells. Jones, E., Adcock, I., Paul, C., & Punchard, N.A. J. Inflamm. 2007, 24: 23.

    38. Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. Chen, L., Zheng, SZ, Sun, ZG, Wang, AY, Huang CH, Punchard, N.A, Huang, SL, Gao, X, Lu, Y. Cancer Chemother Pharmacol. 2011; 68:17-2.

    39. Differential pattern of histone acetylation in inflammatory bowel disease. Tsaprouni, L. Ito, K., Adcock, I., & Punchard, N.A. J. Inflamm. 2011, 8; 1.

    INVITED TALKS

    40. Role of reactive oxygen species in inflammatory bowel disease. 14th British Inflammation Research Association Meeting on the Cellular and Molecular aspects of Inflammatory Bowel Disease, St Thomas' Hospital, London; November 25, 1992.

    41. Reactive oxygen metabolites in gut inflammation. Tissue damage and healing in the human intestine: molecular and cellular mediators. Royal Society of Medicine-Section on Clinical Immunology and Allergy, London. March 8th, 1993.

    42. Immortalisation of human umbilical vein endothelial cells. Vectorial transport in cultured epithelial and endothelial cells. European Tissue Culture Society Workshop. University of Newcastle upon Tyne, April 19th, 1993.

    43. Immortalisation of endothelial cells with Oncogenes. At: "Transformation and immortalisation of mammalian cells". European Tissue Culture Society (UK Branch), University of Sussex. April 6th-8th, 1994

    44. NFkB in Crohn's Disease. Receptor Signalling in Inflammatory cells. British Inflammation Research Association, London; University of East London, April 23rd, 1998.

    45. NFkB in Inflammatory Bowel Disease. Pfizer, Kent. Nov 5/6th, 1998.

    46. Functional Role of immune-cell signalling in the intestine. Nutrition Department, King’s College London. May 30th, 2001.

    CONFERENCE PRESENTATIONS – Published

    47. Leukocyte zinc and prostaglandin production in pregnancy. Simmer, K., Punchard, N.A., Murphy, G., Thompson, R.P.H. Clin. Sci., 1985; 68 (supp. 11), 81-82p.

    48. Zinc and prostaglandins in human pregnancy. Punchard, N.A., Simmer, K., Murphy, G., Thompson, R.P.H. Biochem. Soc. Trans., 1985; 13, 864.

    49. Placental zinc and prostaglandin production in intrauterine growth retardation. Punchard, N.A., Simmer, K., Carlsson, L., Murphy, G., Thompson, R.P.H. Clin. Sci., 1986; 71 (suppl. 15), 31p.

    50. Prostaglandin E2 production by mononuclear cells in Crohn's disease. Satsangi, J., Punchard, N.A., Cason, J., Ainley, C.C., Wolstencroft, R.A., Thompson, R.P.H. Clin. Sci., 1986; 70 (suppl. 13), 11p.

    51. Interleukin-1, prostaglandin E2, trace metals and C-reactive protein in ulcerative proctocolitis. Hubbard, R.B., Punchard, N.A., Cason, J., Carlsson, L.K., Green, A.T., Wolstencroft, R.A., Thompson, R.P.H. Clin. Sci., 1987; 72 (suppl. 16), 50p.

    52. Alterations in leukocyte prostaglandin production in ulcerative proctocolitis. Punchard, N.A., Hubbard, R.B., Cason, J., Green, A.T., Wolstencroft, R.A., Thompson, R.P.H. Biochem. Soc. Trans., 1987; 15, 631-2.

    53. Erythrocyte superoxide dismutase activity in pre-eclampsia. Punchard N.A., Berry, R.M., Berry, MacLachlan, N.A., Thompson, R.P.H. Clin. Sci., 1988; 74 (suppl. 18), 27p.

    54. Measurement of non-protein bound zinc with commercially available filters. Taylor, J.A., Punchard N.A., Murphy, G.M., Thompson, R.P.H. Clin. Sci., 1988; 74 (suppl. 18), 39p.

    55. Plasma glutathione peroxidase activity in pre-eclampsia. Berry, R.M., Punchard, N.A., MacLachlan, N.A., Thompson, R.P.H Clin. Sci., 1988; 75 (suppl. 18), 43p.

    56. Oxygen uptake in peroxide-stressed human red blood cells; a method for assessing anti-oxidant defences. Berry, R.M., Punchard N.A., MacLachlan, N.A., Thompson, R.P.H. Biochem. Soc. Trans., 1988; 16, 284-5.

    57. Resistance of erythrocytes to lipid peroxidation in alcoholic liver disease. Punchard, N.A., Berry, R.M., Mine, P., Thompson, R.P.H. Clin. Sci, 1989; 76 (suppl. 20), 10p.

    58. An inhibitor of interleukin-1 in Crohn's disease. Dalley, C.C., Avery J.A., Punchard, N.A., Cason, J., Wolstencroft, R.A., Thompson, R.P.H. Gut, 1989; 29, A1436.

    59. Inhibition of lipid peroxidation by sulphasalazine and 5-aminosalicylic acid (5-ASA). Punchard, N.A., Berry, R.M., Thompson, R.P.H. Gut, 1989; 29, A1481.

    60. Effect of essential fatty acid supplementation on red cell lipids in ulcerative proctocolitis. Green, A.T., Howell, S. Punchard, N.A., Thompson, R.P.H. Gut, 1989; 30, A717.

    61. Red cell (RBC) lipid peroxidation, superoxide dismutase (SOD) and related enzyme in iron deficient primary proliferative polycythaemia (PPP). Acharya, J., Taylor, J.A., Berry, R.M., Punchard, N.A., Thompson R.P.H. & Pearson, T.C. British Journal of Haematology, 1989; 71 (suppl. 1), 18.

    62. Sulphasalazine promotes mononuclear prostaglandin production. Punchard, N.A., Boswell, D.J. & Thompson R.P.H. Gut 1989; 30, A1451.

    63. Improved radioimmunoassay of prostaglandins with commercial antisera. Punchard, N.A., Murphy, G.M. & Thompson, R.P.H. Biochem. Soc. Trans., 1989; 17, 1097-8.

    64. Reduced susceptibility of erythrocytes to lipid peroxidation in severe alcoholic cirrhosis. Senturk, H., Punchard, N.A., Thompson, R.P.H. Clin. Sci., 1990; 78 (suppl. 22), 35-6.

    65. Diamine oxidase (DAO) in normal and pre-eclamptic (PET) pregnancies. Punchard, N.A., Kalia, V., MacLachlan, N.A., Murphy, G.M., Thompson, R.P.H. Clin. Sci., 1990; 78 (suppl. 22), 35-6.

    66. Effects of acetyl 5-aminosalicylic acid on lipid peroxidation and prostaglandin production. Greenfield, S.M., Boswell, D, Punchard, N.A., Thompson, R.P.H. Gut, 1990; 31, A595.

    67. Indomethacin delays fracture healing by inhibition of prostaglandin production. Taylor, G.J., Punchard, N.A., Wilson N., Heatley, F., Thompson, R.P.H. Clin. Sci., 1991; 80 (suppl. 24), 35p.

    68. Diamine oxidase activities in inflammatory bowel disease (IBD) during pregnancy. Hudson, M., Greenfield, S., Punchard, N.A., Murphy GM, Thompson RPH, Pounder RE. Gut, 1991; 32, A593.

    69. Trial of essential fatty acids in the treatment of ulcerative proctocolitis. Green, AT, Punchard, N.A., Thompson, R.P.H. Gut, 1991; 32, A592.

    70. Leukocyte adhesion molecule expression in inflammatory bowel disease. Greenfield S.M., Hamblin, Punchard, N.A., Thompson, R.P.H. Clin. Sci., 1991; 81 (Suppl. 25), 12p.

    71. Inhibition of leukocyte adhesion molecule expression: a novel mechanism of action of sulphasalazine. Greenfield, S.M., Hamblin, A.S., Punchard, N.A., Thompson R.P.H. Gut 1991; 32, A1228.

    72. Mononuclear cell prostaglandin production in Crohn's disease (CD) and ulcerative colitis (UC). Boswell, D.J. , Greenfield, S.M., Thompson R.P.H., Punchard, N.A. Clin. Sci. 1992; 82,24p.

    73. Prostacyclin production in normal and immortalised umbilical endothelial cells. Boswell, D.J., Biggerstaff, J.P., Wilbourn, B.R., Thompson R.P.H., Punchard, N.A., Clin. Sci. 1992; 82, 19p.

    74. Effect of Thyroidectomy and adrenalectomy upon liver glutathione and malonaldehyde in response to acute ethanol injection. Teare J.P., Punchard N.A., Greenfield S.M., Marway J.S. Preedy V.R., Peters T.J., Thompson R.P.H. Gastroenterology 1992; 102, A900.

    75. Final results of a controlled trial of fatty acid supplementation in maintenance treatment of ulcerative colitis. Greenfield S.M., Green A.T., Teare J.P., Punchard N.A., Thompson R.P.H. Gastroenterology 1992; 102, A631.

    76. Differences in tumour necrosis factor a (TNFa) levels between children and adults with inflammatory bowel disease. Greenfield S.M., Plamer S, Hamblin A.S., Teare J.P., Punchard N.A., Thompson R.P.H.: Gastroenterology 1992; 102, A632.

    77. Evidence for lipid peroxidation in rats chronically fed alcohol. Teare J.P., Greenfield S.M., Punchard N.A., Watson D., Thompson R.P.H. Gut 1992; 33, S25.

    78. Effect of thyroidectomy upon hepatic glutathione and malonaldehyde levels in response to acute ethanol injection. Teare J.P., Punchard N.A., Preedy V.R., Marway J.S., Thompson R.P.H. International Journal of Radiation. 1992; 62, p16.

    79. The effect of hydrogen peroxide (H2O2) on endothelial cell prostacyclin (PGI2) production. Boswell, D.J., Greenfield, S.M., Thompson, R.P.H., Punchard, N.A. International Journal of Radiation. 1992; 62, p111.

    80. DAO binding to human umbilical endothelial cells (HUVEC). Engleman, J.L., Stubbs, A.P. Qureshi, M.Y., Punchard, N.A., Murphy G.M., Sladen G.E. Gastroenterology 1993; 104, p246.

    81. Aminosalicylate therapy increases prostaglandin production in ulcerative colitis. Greenfield, S.M., Punchard, N.A., Boswell, D.J. & Thompson, R.P.H. Gut 1993; 34, S52.

    82. Sulphasalazine and 5-ASA reduce leukocyte adhesion to vascular endothelium. Greenfield, S.M., Punchard, N.A., Boswell, D.J., Thompson, R.P.H. Gut 1993; 34, S53.

    83. Chronic ethanol administration increases gastric mucosal prostaglandin production. Punchard, N.A., Watson, D.J., Teare, J.P., Thompson, R.P.H. Clin. Sci. 1993; 84, p357.

    84. Use of viral and cellular oncogenes to immortalise endothelial cells. Punchard, N.A., Jewers, R.J., Sankey, M.D., Watson, D.J., Kell, B., Cason, J., Best, J.M., Thompson, R.P.H. Biochem. Soc. Trans. 1994; 22. 197S

    85. Analysis of glutathione in endothelial cells grown in 96 well microtitre plates. Punchard, N.A., Watson, D.J., Thompson, R.P.H. Biochem. Soc. Trans. 1994; 22. 198S

    86. Effects of alcohol on gastric prostaglandin production and glutathione status. Punchard, N.A., Watson, D.J., Teare, J.P., Thompson, R.P.H. Biochem. Soc. Trans. 1994; 22. 196S

    87. Human papillomavirus type 16 DNA can immortalise endothelial cells in vitro. Jewers, R.J., Punchard, N.A., Kell, B., Watson, D.J., Sankey, M.D., Thompson, R.P.H., Best, J. J Cell Biochem 1994; S18C; p223.

    88. Activation of NFkB in the bowel. Ellis, R., Punchard, N.A., Limb, G.A., Jones, S.E., Thompson, R.P.H. Inflammation Research, Suppl. 3, 44, S268, 1995.

    89. Utilisation of the MTT assay for studies on trout lymphocytes. Thompson, E., Panchal, R., Bird, D. & Punchard, N.A. Immunology, (suppl., 1996, In Press).

    90. Immunogenic properties of human papillomavirus type 16 (HPV-16) E5 polypeptide. Gill, D., Cason, J., Punchard, N.A. Immunology, 1996; 67 (Suppl. 1) , 35,

    91. The identification of two different sized mRNAs encoding the small Intestinal Na+/bile acid cotransporter: consequences for molecular regulation of the protein. Mullins J.G.Ll, Punchard N.A., & Murphy G.M. Proceedings of the 93rd Falk Symposium (XIV International Bile Acid Meeting), November, 1996.

    92. NFkB in Crohn’s disease. Ellis, R., Limb, G.A., Jones, S.E., Thompson, R.P.H., Punchard, N.A. Immunology 1996; 89 (Suppl.1), 35

    93. Immunogenic properties of human papillomavirus type 16 (HPV-16) E5 polypeptide. Gill, D., Cason, J., & Punchard, N.A. Biochemical Society Transactions, 1997; 25, 281S

    94. NF-kappa-B in Crohn’s disease. Ellis, R., Limb, G.A., Jones, S.E., Thompson, R.P.H., Punchard, N.A. Biochemical Society Transactions, 1997; 25 , 178S

    95. HPV-16 E5 Induced lymphocyte responses in cervical neoplasia. Biswas, C., Gill, D.K., Raju, K.S., Best J.M., Punchard, N.A. & Cason, J., British Journal of Cancer, 1997; 76 (suppl 1), 40.

    96. Activation of the transcription factor NFkB in Crohn’s disease. Ellis, R., Limb, G.A., Jones, S.E., Thompson, R.P.H. & Punchard, N.A., Gastroenterology 1997; 112 (4 suppl), A996 .

    97. Effect of the bile acid: fatty acid ratio on in vivo essential fatty acid absorption in the rat. Mullins J.G.Ll., Green A.T., Thompson R.P.H., Punchard N.A. Biochemistry Society Transactions, 1998; 26, S178.

    98. Effects of macrophage-colony stimulating factor and interleukin-1b on glycosaminoglycans and nitric oxide production. Stephan S, Purcell, WM., Punchard, N., Chander, CL. Br. J. Rheum. 1998; 37 (suppl. 2), 4

    99. Eosinophils & in situ hybridisation. Ellis, R., Punchard, N.A., Taylor, P., Powell J.J., & Thompson, R.P.H., Gastroenterology 1998; 114 (4 part 2), A366 .

    100. Prostaglandin E2 production in articular cartilage is enhanced by granulocyte macrophage colony stimulating factor and interleukin-3 when combined with interleukin-1b. Stephan S, Purcell, WM., Punchard, N., Chander, CL. Mediators of Inflammation 1999; 8 (suppl.1) S78.

    101. Stimulation of human U937 monocytes with LPS induces histone acetylation. Tsaprouni, L. Ito, K., Adcock, I., & Punchard, N.A. Immunology 2001; 101 (suppl. 1) 25.

    102. NFkB in the TNBS model of colonic Inflammation. Jones, E., Bourne, T., Adcock, I., Paul, C., & Punchard, N.A. Immunology 2001; 101 (suppl. 1) 88..

    103. Inhibition of LPS-stimulated monocyte NO production by PMA: role of NFkB. Jones, E., Adcock, I., Paul, C., & Punchard, N.A. Immunology 2001; 101 (suppl. 1) 24.

    104. Gata-6 expression and TNFa secretion in IL-17 stimulated human monocytes. Wheeler, J., A., Punchard, N.A. & Adcock, I. Immunology 2000; 101 (suppl. 1) 25.

    105. Evidence of NMDA receptor involvement in neuroinflammation and BBS disruption during EAE. Bushell, J.A., Bolton, C., Punchard, N.A. & Paul, C. Immunology 2001; 101 (suppl. 1 ) 52. (Note: selected oral presentation)

    106. NFB activity and inflammation of the bowel. E. Jones, T. Bourne1, I. Adcock2, S Pereira3, C. Paul & N.A. Punchard. (Presented at the IAIS “World Congress on Inflammation”,Edinburgh, Sept. 22-36th 2001. Inflammation Research, 2001; 50 (suppl. 3), S168.

    107. Histone acetylation and inflammation of the bowel. L. Tsaprouni, I. Adcock2, S. Evans3, C. Paul, R.P.H Thompson3 & N.A. Punchard (Selected Oral Presentation at the IAIS “World Congress on Inflammation” in Edinburgh, Sept. 22-36th 2001. Inflammation Research, 2001 50 (suppl. 3), S224.

    108. Increased levels of histone acetylation in the inflamed bowel. Tsaprouni, L., Ito, K., Adcock, I., Evans, S., Punchard, N.A. (Presented at the British Society for Immunology Congress, Harrogate, 2001). Immunology 2001; 104 (suppl. 1), 126-7.

    109. Increased IkBa levels in the inflamed bowel. Jones, E., Peiera, S., Bourne, T., Adcock, I. & Punchard, N.A. . (Presented at the British Society for Immunology Congress, Harrogate, 2001). Immunology 2001; 104 (suppl. 1), 122.

    110. Altered Polyamine synthesis and NMDA receptor expression during experimental allergic encephalomyeltis (EAE). Wheeler, E.R., Walemba, E.M. Bolton, C., Punchard, N.A., Mullins, J.G.L & Paul, C. (Presented at the Biochemical Society Meeting, London, Dec 2002). Biochemical Society Transactions, 2002. 31 (2), No 45.

    111. Evaluation of an in vitro model of granuloma formation. Baker, M. Adcock, I.., Punchard, N.A. (Presented at the British Society for Immunology Congress, Harrogate, 2003). Immunology 2004; 113 (Suppl 1), 111.

    CONFERENCE PRESENTATIONS: NON-PUBLISHED

    112. Zinc and intrauterine growth retardation - are prostaglandins involved? Simmer, K., Punchard, N.A., Murphy, G., Thompson, R.P.H. Paediatric Research Society, St Andrews, 1985.

    113. Placental zinc and prostaglandin production in intrauterine growth retardation. Punchard, N.A., Simmer, K., Carlsson, L., Thompson, R.P.H. Society for Free Radical Research Winter Meeting, Dec. 16th, 1985, London.

    114. Interleukin-1 and prostaglandins in ulcerative colitis. Hubbard, R.B., Punchard, N.A., Cason, J., Green A.T., Wolstencroft R.A., Thompson, R.P.H. British Society of Immunology Meeting, London, November, 1986.

    115. Methods for determination of human erythrocyte antioxidant status. Punchard, N.A., Berry, R.M., Taylor, J.A., Thompson, R.P.H. Society for Free Radical Research Winter Meeting, Dec. 14th, 1987, London.

    116. Sulphasalazine and 5-Aminosalicylic acid: antioxidants or promoters/inhibitors of cyclooxygenase? Punchard, N.A., Greenfield, S.M., Boswell, D.J., Thompson, R.P.H. International Symposium on Free radicals in Biotechnology and Medicine: The Royal Society of Chemistry Analytical Division, London, Feb. 7th 1990.

    117. A trial of essential fatty acids in the treatment of ulcerative proctocolitis. Green, A.T., Punchard, N.A., Thompson R.P.H. Trends in Inflammatory Bowel Therapy, Falk Symposium No. 56., Nova Scotia, Canada, June, 6th 1990.

    118. Sulphasalazine: an antioxidant and promoter of prostaglandin production. Punchard, N.A., Greenfield, S.M., Boswell, D.J., Thompson, R.P.H. Trends in Inflammatory Bowel Therapy, Falk Symposium No. 56., Nova Scotia, Canada, June, 6th, 19

    119. Indomethacin: Affects on bone healing. Taylor G.J., Punchard, N.A., Wilson N., Heatley F., Thompson R.P.H. British Orthopaedic Research Society Spring Meeting, April 12th, 1991.

    120. Adhesion molecule expression in inflammatory bowel disease. Greenfield S.M., Hamblin, A., Punchard, N.A. & Thompson, R.P.H. Joint Meeting of the British and French Immunology Societies, London, 15-17th October, 1991.

    121. Hepatic glutathione and malondialdehyde production after fasting, refeeding and ethanol. Teare J.P., Greenfield S.M., Preedy V.R, Punchard N.A., Peters T.J. and Thompson R.P.H. "Function of glutathione in gut and liver" in Basel, Germany. Oct. 21st, 1992.

    122. Immortalisation of human endothelial cells using human papillomavirus type 16. Jewers, R.J., Punchard N.A., Sankey, M.D., Watson D.J., Kell B, Cason J, Best J., Thompson RPH. 9th International Congress of Virology, Glasgow , 8-13th August 1993.

    123. Characterisation of immune responses to human papillomavirus type-16 E5 protein. Gill, D.K., Biswas, C., Raju, K.S., Best J.M., Punchard, N.A. & Cason, J. Eurogen 3rd International Conference; Lower Genital Tract Infections and Neoplasia, Future Challenges and Strategies. Paris, France 1997.

    124. T-cell responses to HPV-16 E5. Gill DK, Bible JM, Biswas C, Raju KS, Best JM, Punchard NA & Cason J. 16th International Papillomavirus Conference, Sienna. 1997.

    125. Prostaglandin E2 production in articular cartilage is enhanced by granulocyte macrophage colony stimulating factor and interleukin-3 when combined with interleukin-1b. Stephan S, Purcell, WM., Punchard, N., Chander, CL. (Inflammation ’99, Paris, June 27th-30th, 1999)

    126. Plasma nitric oxide status following a bout of resistance training. Porter-Blake A, Paul C, Aston T, Punchard, N.A. (5th Annual Congress of the European College of Sports Science, Finland, 2000

    127. Comparison of cytokine production and apoptosis in U937 cells by stimulation with LPS, H2O2 and TNF-a

    128. Tsaprouni, L. Ito, K, Adcock, I., & Punchard, N.A Cell and Molecular Biology of Apoptosis, Heriot-Watt University, Edinburgh. Sept 10-13th, 2000.

    OTHER OUTPUT

    129. Chemokine Receptors.. Wallace G & Punchard N. Immunology News. Nov./Dec., 1998; pp 238-9.

    130. Inflammation and the Vascular Endothelium. Punchard N. Immunology News. Nov./Dec. 1999; 273.

    131. The Endothelium and Inflammation. Punchard, N. & Paul, C. Inflammation Research 2000; 49, 438-440. (Also published as: Inflammation and the Vascular Endothelium. Punchard, N. & Paul, C.. Immunology News. June, 20000; 7.3, 10-11.)

    132. Named Reviewer for: "Prolonged Release Mesalazine: A review of its therapeutic Potential in Ulcerative Colitis and Crohn's disease. Clemett, D. & Markham, A. Drugs, 2000, 929-956

    133. Resistance to conventional and novel insecticides in the glasshouse whitefly, Trialeurodes vaporariorum. Gorman K., Denholm I., Punchard N.A., and Gray S. (2002) Proceedings IACR-student symposium (unpublished)

    134. Resistance To Conventional And Novel Insecticides In The Glasshouse Whitefly, Trialeurodes Vaporariorum. Kevin Gorman, K., Denholm, L., Coussons, P. Punchard, N.A. (2003) Proceedings IACR-student symposium (unpublished).

    Publications

    Previous Research funding Sources: University of Luton; South East Thames Regional Health authority; University of London; The Special Trustees of St Thomas' Hospital; National Association for Colitis and Crohn's Disease (NACC); Peel Medical Research Trust; Lambeth Endowed Charities; Astra Foundation; G.D. Searle; Paterson Charitable Trust; HEFCE (RAE); Biochemical Society and Yakult. While at St Thomas’ I was twice short-listed for Welcome Senior Fellowships and had an Medical Research Council application rated as α+.

    Funding




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