Dr Eva Galante
Medicines Research Group, School of Health, Sport and Bioscience
Eva Galante studied Chemistry as an undergraduate and postgraduate at the University of Catania, Italy. As a postgraduate she won a 2004 research fellowship at the Consiglio Nazionale delle Ricerche (CNR), during which she investigated natural products chemistry. In 2010, she acquired her PhD in Chemical Science from the University of Catania, where she had worked on the development of anti-tumour vaccine candidates based on tumour-associated glycomimetic antigens. As part of her doctoral programme, she spent a year at the John Innes Centre in Norwich researching new glycoconjugates acting as anti-parasite against Trypanosoma cruzi. Dr Galante has served as a postdoctoral researcher at the University College of London, where she initially worked on the development of new tracers for positron emission tomography (PET) imaging of brain proteins associated with neurological disease and responsible for drug resistance, and subsequently on the development of chemotherapeutic agents against neuroblastoma. After serving as a teaching fellow in Chemistry at Queen Mary University of London, she was appointed Lecturer in Chemistry at the University of East London. Dr Galante's primary research interest lies in medicinal chemistry, with particular focus on natural products and investigation of new treatments for solid tumour.
K. Sander, E. Galante, T. Gendron, E. Yiannaki, N. Patel, T.L. Kalber, A. Badar, M. Robson, S.P. Johnson, F. Bauer, S. Mairinger, J. Stanek, T. Wanek, C. Kuntner, T. Kottke, L. Weizel, D. Dickens, K. Erlandsson, B.F. Hutton, M.F. Lythgoe, H. Stark, O. Langer, M. Koepp, E. Årstad. Development of fluorine-18 labeled metabolically activated tracers for imaging of drug efflux transporters with PET. J. Med. Chem. 2015, 58, 6058 – 6080.
G.M.L. Consoli, G. Granata, E. Galante, I. Di Silvestro, L. Salafia, C. Geraci. Synthesis of water-soluble nucleotide-calixarene conjugates and preliminary investigation of their in vitro DNA replication inhibitory ability. Tetrahedron, 2007, 63, 10758 – 10763.
G.M.L. Consoli, G. Granata, E. Galante, F. Cunsolo, C. Geraci. Novel nucleotide-calixarene conjugates via phosphoester linkage. Tetrahedron Lett., 2006, 47, 3245 – 3249. G.M.L. Consoli, E. Galante, C. Daquino, G. Granata, F. Cunsolo, C. Geraci. Hydroxycinnamic acid clustered by a calixarene platform: radical scavenging and antioxidant activity. Tetrahedron Lett.,2006, 47, 6611 – 6614.
M. Della Peruta, A. Badar, C. Rosales, S. Chokshi, A. Kia, D. Nathwani, E. Galante, R. Yan, E. Årstad, A.M. Davidoff, R. Williams, M.F. Lythgoe, A.C. Nathwani. Preferential targeting of disseminated liver tumors using a recombinant adeno-associated viral vector. Hum. Gene Ther. 2015, 26, 94 – 103.
E. Galante, T. Okamura, K. Sander, T. Kikuchi, M. Okada, M-R. Zhang, M. Robson, A. Badar, M.F. Lythgoe, M. Koepp, E. Årstad. Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET. J. Med. Chem. 2014, 57, 1023 – 1032.
C. Geraci, G.M.L. Consoli, G. Granata, E. Galante, A. Palmigiano, M.S. Pappalardo, S. Di Puma, A. Spadaro. The first self-adjuvant multicomponent potential vaccine candidates by tethering of four or eight MUC1 antigenic immunodominant PDTRP units on a calixarene platform: synthesis and biological evaluation. Bioconjugate Chem. 2013, 24,1710 – 1720.
E. Galante, B.W. Schoultz, M. Koepp, E. Årstad. Chelator-accelerated one-pot ‘click’ labeling of small molecule tracers with 2-[18F]fluoroethyl azide. Molecules 2013, 18, 5335 – 5347.
R. Yan, K. Sander, E. Galante, V. Rajkumar, A. Badar, M. Robson, E. El-Emir, M.F. Lythgoe, R.B. Pedley, E. Årstad. A One-pot three-component radiochemical reaction for rapid assembly of 125I-labeled molecular probes. J. Am. Chem. Soc. 2013, 135, 703 – 709.
E. Galante, C. Geraci, S. Sciuto, V.L. Campo, I. Carvalho, R. Sesti-Costa, P.M.M. Guedes, J.S. Silva, L. Hill, S.A. Nepogodiev, R.A. Field. Glycoclusters presenting lactose on calixarene cores display trypanocidal activity. Tetrahedron, 2011, 67, 5902 – 5912.
C. Sgarlata, V. Zito, G. Arena, G.M.L. Consoli, E. Galante,C. Geraci. A sinapic acid-calixarene hybrid selectively binds Pb2+ over Hg2+ and Cd2+. Polyhedron, 2009, 343 – 348.
C. Geraci, G.M.L. Consoli, E. Galante, E. Bousquet, M. Pappalardo, A. Spadaro. Calixarene decorated with four Tn antigen glycomimetic units and P3Cs immunoadjuvant: synthesis, characterization and anticancer immunological evaluation. Bioconjugate Chem. 2008, 19, 751 – 758.
Natural compounds chemistry
Design of small molecules as chemotherapeutic agents
Pre-clinical evaluation of novel drugs