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Dr David Guiliano

Head of the Department of Bioscience

Infection and Immunity , Applied Sport and Exercise Science

As Head of Department Dr. Guiliano oversees the delivery and growth of a variety of undergraduate and post-graduate courses within the Biosciences. In addition, to managing the department he is also actively engaged in teaching, research, and supervising post graduate students. He also chairs the school’s Health and Safety committee and is head link for academic partnerships.

  • School of Health, Sport and Bioscience
    University of East London, Stratford Campus
    Water Lane
    London
    E15 4LZ
  • d.guiliano@uel.ac.uk

    Dr. David Guiliano is the Head of the Department of Bioscience in the School of Health Sport and Bioscience (HSB) at UEL. 

    He completed his PhD. in Molecular Parasitology and Genomics in the Institute of Cell Animal and Population Biology at the University of Edinburgh in 2002. After completing his PhD. he held post-doctoral research appointments and research fellowships in various institutions including the School of Medicine at UCL and the Immunology Unit in the London School of Hygiene and Tropical Medicine. He was also awarded a Wellcome trust advanced training fellowship which he completed in the Deptartment of Biological Sciences at Imperial College London. 

    Dr. Guiliano joined the UEL Bioscience faculty in 2011 and has held a number of positions within the school including course leader for the BSc Biomedical Science course, Research Degrees Leader, head link for academic partnerships, chair of the HSB Health and Safety Committee and subject head in Bioscience. He became the Head of Department for Bioscience in 2017.

     



    As Head of Department Dr. Guiliano oversees the delivery and growth of a variety of undergraduate and postgraduate courses within the Biosciences. In addition, to managing the department he is also actively engaged in teaching, research, and supervising post graduate students. He also chairs the school’s Health and Safety committee and is head link for academic partnerships.
    Qualifications:  PhD., FHEA, FIBMS
    Tier 1 and Tier 2 external examiner at Middlesex University

    Overview

    Dr. Guiliano’s research focuses on identifying novel intervention strategies for infectious diseases including rational drug and vaccine design for combating antimicrobial resistance in bacteria and parasites.

    His group is currently focused on mining genome data of these organisms utilizing in silico modeling and drug docking software to assist in the  isolation of novel drugable targets. He part of an international collaborative effort to develop a mucosal vaccination system using transgenic probiotic organisms to deliver vaccinogens and accessory immuno-stimuli to the gastrointestinal mucosa. He is also interested in understanding the mechanisms by which pathogens dysregulate or avoid immune responses.  Currently his group is characterizing the activities of immuno-modulatory proteins secreted by gastrointestinal pathogens as many of these organisms occupy intracellular niches and utilize secreted effector molecules to both subvert the biology of the cells they infect and their host’s immune responses. In particular they are focused on elucidating the activities of parasite cytokine homologues derived from the parasitic nematode Trichinella spiralis on epithelial and antigen presenting cells and other secreted proteins in the transformation of skeletal muscle into nurse cells.

    Dr. Guiliano is a member of the Infection and Immunity research group within HSB.

    Most recent research

    Some of Dr. Guiliano’s most recent publications have focused on novel vaccine development in the parasitic nematode Trichinella spiralis (Srey et al. 2020) and development of novel biopharmaceuticals (Collins et al. 2021). 

    Collaborators

    • test

    Research

    Most recent publications:


    Collins M, Awwad S, Ibeanu N, Khaw PT, Guiliano D, Brocchini S, Khalili H. (2021) Dual-acting therapeutic proteins for intraocular use Drug Discovery Today. 2021 Jan;26(1):44-55. doi: 10.1016


    Srey MT, Taccogna A, Oksov Y, Lustigman S, Tai PY, Acord J, Selkirk ME, Lamb TJ, Guiliano D.B. (2020) PLoS Negl Trop Dis. 2020 Nov 18;14(11): e0008842. doi: 10.1371


    Guiliano D.B., North H, Panayoitou E, Campbell EC, McHugh  K,  Cooke  FG,  Silvestre  M,  Bowness  P, Powis SJ, Antoniou AN. (2017) Polymorphisms in the F Pocket of HLA-B27 Subtypes Strongly Affect Assembly, Chaperone Interactions, and Heavy-Chain Misfolding. Arthritis Rheumatol. Mar; 69(3):610-­‐621. 


    Guiliano D.B. (2012) Introduction to helminth infections Lamb, T.J. (Editor) Immunity to Parasitic Infection, Wiley-Blackwell


    Guiliano D.B. and Antoniou A. (2012) Measuring Synthesis and Degradation of MHC Class I Molecules, Methods in Molecular Biology, Methods in Antigen Processing and Presentation Approaches, van Endert, P. (Editor) Springer


    Antoniou A.N., Lenart I., Guiliano, D.B. and Powis S.J. (2012) Antigen processing and presentation by MHC I, II, and non-classical molecules, Morrow J.H., Schmidt C, Sheikh N., Davies, H. (Editors) Vaccinology: Principles and Practice Wiley-Blackwell


    Guiliano, D.B. and  Oksov, Y, (2009) Trichinella and the nurse cell “Intracellular niches of microbes” Edited by Schaible U.E. and Haas A. Wiley- VCH, Weinheim., Fussell H, Lenart I, Tsao E, Nesbeth D, Fletcher AJ, Campbell EC, Yousaf N, Williams S, Santos S, Cameron A, Towers GJ, Kellam P, Hebert DN, Gould KG, Powis SJ, Antoniou AN. (2014) Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis Rheumatol. Nov;66(11):2976-88 


    Hudson, L.E., Fasken, M.B., McDermott, C.D., McBride, S.M., Kuiper, E.G., Guiliano, D.B., Corbett, A.H., Lamb,  T.J.  (2014) Functional  Heterologous Protein Expression by Genetically Engineered Probiotic Yeast Saccharomyces boulardii, PLoS ONE, 9(11): e112660 


    Antoniou A. N., Guiliano D.B., Lenart I., Burn G. and Powis S. (2011) The redox status of HLA-B27 and the influence on biosynthesis Antioxidants and Redox Signaling Aug 1;15(3):669-84


    Lenart I., Guiliano D. B. , Burn G., Campbell E.C., Morley K.D., Fussell H., Powis S. and Antoniou A. N. (2011) The MHC Class I Heavy Chain Structurally Conserved Cysteines 101 and 164 Participate in HLA-­‐ B27 Dimer Formation. Antioxidants and Redox Signaling Aug 1;15(3):669-84  joint first author


    Antoniou A.N., Lenart I., Guiliano, D.B. (2011) Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules, International Journal Rheumatology ;2011:486856. 


    Guiliano, D.B., Oksov, Y, Lustigman S., Gounaris K., and Selkirk M.E. Characterisation of novel protein families secreted from the muscle stage larvae of Trichinella spiralis. (2009) Int. J. of Parasitology Apr;39(5):515-24


    Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J., Delcher, A., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, T., Haas, B., El-Sayed, N., Wortman, J., Feldblyum, T., Tallon, F., Schatz, M., Shumway, M., Koo, H., Schobel, S., Pop, M., Barton, G., Carlow, C. S., Crawford, M. J., Daub, J., Dimmic, M., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, J., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B., Li, W., Lindblom, T., Lustigman, S., Ma, D., Maina, C., Martin, D., McCarter, J. P., McReynolds, L., Mitreva, M., Parkinson, J., Peregrin, J., Poole, C., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T., Ware, J., Wei, A., Weil, G., Williams, D., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M., and Scott, A. (2007) Genome Sequence of the Parasitic Nematode Brugia malayi: The Biology of Parasitism. Science Sep 21;317 (5845):1756-60

    Contributions to Chapters in Books
    Guiliano D. B. and Lamb T.J. (2012) Introduction to protozoan infections Lamb, T.J. (Editor) Immunity to Parasitic Infection, Wiley-Blackwell


    Guiliano D.B.
    (2012) Introduction to helminth infections Lamb, T.J. (Editor) Immunity to Parasitic Infection, Wiley-Blackwell


    Guiliano D.B.
    and Antoniou A. (2012) Measuring Synthesis and Degradation of MHC Class I Molecules, Methods in Molecular Biology, Methods in Antigen Processing and Presentation Approaches, van Endert, P. (Editor) Springer


    Antoniou A.N., Lenart I., Guiliano, D.B. and Powis S.J. (2012) Antigen processing and presentation by MHC I, II, and non-classical molecules, Morrow J.H., Schmidt C, Sheikh N., Davies, H. (Editors) Vaccinology: Principles and Practice Wiley-Blackwell


    Guiliano, D.B.
    and  Oksov, Y, (2009) Trichinella and the nurse cell “Intracellular niches of microbes” Edited by Schaible U.E. and Haas A. Wiley- VCH, Weinheim.

    Publications


    Funding

    Immunology, Microbiology, Parasitology, Vaccine Development, Novel Therapeutic Strategies


    Interests

    Portfolio

    Along with his research activities and duties as Head of Department , Dr. Guiliano also teaches on a variety of modules within the undergraduate and post-graduate programs focusing on molecular biology, cancer, microbiology, parasitology, vaccinology, immunology, and infectious disease control.

    Dr. Guiliano became a Fellow of the Higher Education Authority in 2013 and is a Fellow of the Institute of Biomedical Sciences. He is a member of the British Society for Immunology, Society for Applied Microbiology, Society for General Microbiology and Biochemical Society.

    Teaching