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Dr Stefano Casalotti

Senior Lecturer

Medicine Research Group, Bioscience

Interested in the biological basis of substance misuse  and addiction, and creating appropriate learning environments



    My main current research interest is understanding the molecular mechanism that support behavioural changes following use or misuse of psychoactive substances. We use the fruit fly Drosophila  to address questions about the changes in gene expression that occur following exposure to alcohol  and how some of these changes and behavioural changes  can be regulated through pharmacological intervention.  My interests in cellular and molecular mechanism is reflected in my teaching in modules of Biochemistry and Cellular and Molecular Biology. I also have a broader interest in how teaching practices need to evolve making use of current technologies and methodologies to create effective learning environments. I strongly believe that Universities are 'learning' institutions and not 'teaching' institution where learning is a joint action between students and academics.
    Senior Fellow of Higher Education Academy

    Overview




    I Brunetta , SO Casalotti , IR Hart, A Forge, LE Reynolds. (2012) beta3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear. BMC Cell Biol. 2012 Mar 17;13(1):5.
    N Ruksee, W Tongjaroenbuangam, SO Casalotti, P Govitrapong. (2008) Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats. BMC Neurosci. 9: 99.
    W Tongjaroenbuangam, N Jongkamonwiwat, P Phansuwan-Pujito, SO Casalotti, A Forge, H Dodson, P Govitrapong. (2006) Relationship of opioid receptors with GABAergic neurons in the rat inferior colliculus.. Eur J Neurosci.;24(7):1987-94..


    Collaborators

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    Research

     beta3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear.

    I Brunetta , SO Casalotti , IR Hart, A Forge, LE Reynolds.. 2012.  BMC Cell Biol. Mar 17;13(1):5..

    N Jongkamonwiwat, P Phansuwan-Pujito, SO Casalotti, A Forge, H Dodson, P Govitrapong. (2006) The existence of opioid receptors in the cochlea of guinea pigs. Eur J Neurosci. 23:2701-11.

    P E.M. Martin, S. L..Coleman, S. O. Casalotti, A. Forge and W.H. Evans (1999) Properties of connexin26 gap junctional proteins derived from mutations associated with non-syndromal hereditary deafness Human Molecular genetics. 8:2369-2376

    B. Chetsawang, S.O. Casalotti, P. Phansuwan-Pujito, N. Kotchabhakdi, P. Govitrapong (1999) Gene expressions of opioid receptors and G-proteins in pineal glands. Biochem Biophys Res Commun 262:775-80

    G.S.G. Geleoc, S.O. Casalotti, A. Forge and J.F. Ashmore (1999) A sugar transporter as a candidate for the outer hair cell motor. Nature Neuroscience 2, 713-719.

    E. Kumarnsit, P. Harnyuttanakorn, D. Meksuriyen, P. Govitrapong, B.A. Baldwin, N. Kotchabhakdi and S.O. Casalotti (1999) Pseudoephedrine, a Sympathomimetic Agent, Induces Fos-like Immunoreactivity in Rat Nucleus Accumbens and Striatum. Neuropharmacology, 38, 1381-1387

    A. Forge, D. Becker, S. O. Casalotti, J. Edwards, W.H. Evans, N. Lenh and M. Souter (1999) Gap junctions and connexin expression in the inner ear. In Novartis Foundation Symposium 219: “Gap Junction-Mediated Intercellular Signalling in Health and Disease” J. Wiley & Sons Ltd pp 134-156.

    P. Sirirpurkpong, P. Harnyuttanakorn, C. Chindadoungratana, N. Kotchabhakdi, P. Wichyanuwat and S.O. Casalotti. (1997) Dexamethasone, but not stress, alters mitochondrial benzodiazepine receptor gene expression in rat. European Journal of Pharmacology 331, 227-235.

    J.Wattanathorn, N. Kotchabhakdi, S.O. Casalotti, B.A. Baldwin and P. Govitrapong. (1996) Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase. European Journal of Pharmacology 313, 69-72S. O. Casalotti, A.P. Kozikowski, A Fauq, W. Tückmantel and K.E. Krueger (1993) Monoclonal antibodies against a phencyclidine derivative are used to investigate protein-ligand interaction. European Journal of Pharmacology. (Molecular Pharmacology Section.) 247, 209-213.

    S.O. Casalotti, G. Pelaia, A. G. Yakolev, T. Csikós, D. R. Grayson, K.E. Krueger. (1992) Structure of the rat gene encoding the mitochondrial benzodiazepine receptor Gene, 121, 377-382.

    S. O. Casalotti, A.P. Kozikowski, A Fauq, W. Tückmantel and K.E. Krueger. (1992) Design of an irreversible affinity ligand for the phencyclidine recognition site on N-methyl-D-aspartate-type glutamate receptors. Journal of Pharmaceutical and Experimental Therapeutics, 260, 21-28.

    A.P. Kozikowski, A.H. Fauq, W.Tuckmantel, S.O. Casalotti and K.E.Krueger. (1991) Synthesis of TCP-based irreversible alkylators of the PCP recognition site. Synletters. 9, 654-655

    W Tongjaroenbungam, N Jongkamonwiwat, J Cunningham, P Phansuwan-Pujito, HC Dodson, A Forge, P Govitrapong, SO Casalotti. (2004), Opioid modulation of GABA release in the rat inferior colliculus BMC Neuroscience 5:31

    F.A.Stephenson, M.J. Duggan and S.O. Casalotti. (1989) Identification of the Alpha-3 Subunit in the GABAA Receptor Purified from Bovine Brain. Febs Letters., 2443 358-62.

    S.O. Casalotti, F.A. Stephenson and E.A. Barnard. (1986) Separate Subunits for Agonist and Benzodiazepine Binding in the Aminobutyric Acid-A Receptor Oligomer. Journal of Biological Chemistry. 261, 15013-15016.

    F.A Stephenson, S.O. Casalotti, C. Mamalaki and E.A. Barnard. (1986) Antibodies Recognising the GABAA/Benz.

    A Forge, Marziano NK, Casalotti SO, Becker DL, Jagger D. (2003) The inner ear contains heteromeric channels composed of cx26 and cx30 and deafness-related mutations in cx26 have a dominant negative effect on cx30. Cell Commun Adhes. 10:341-6. A Forge, Becker D, Casalotti S, Edwards J, Marziano N, Nevill (2003) G. Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessment of connexin composition in mammals. J Comp Neurol. 467:207-31.

    P. Phansuwan-Pujito, L. Saleema , S. Mukda, N. Jutapakdeegul, S.O. Casalotti, A. Forge, H. Dodson, P. Govitrapong (2003) The opioid receptors in inner ear of different stages of postnatal rats. Hear Res. 184:1-10.

    N. Jutapakdeegul, SO Casalotti, P Govitrapong, N Kotchabhakdi. (2003) Postnatal touch stimulation acutely alters corticosterone levels and glucocorticoid receptor gene expression in the neonatal rat. Dev Neurosci.;25(1):26-33.

    N. Jongkamonwiwat, P. Phansuwan-Pujito, P. Sarapoke, B. Chetsawang, S.O. Casalotti, A. Forge, H. Dodson, P. Govitrapong (2003) The presence of opioid receptors in rat inner ear. Hearing Research 181: 85-93.

    NK Marziano, SO Casalotti, AE Portelli, DL Becker, A Forge. Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30. Hum Mol Genet. (2003) 12: 805-12

    A Forge, D Becker, S O Casalotti, J, Edwards N Marziano, R Nickel. (2002) Connexins and gap junctions in the inner ear. Audiol Neurootol.;7:141-5

    S.Kaewsuk, P. Hutamekalin, A. Ketterman, N Khotchabhakdi, P.Govitrapong, S.O.Casalotti (2001) Morphine induces short-lived changes in G-protein gene expression in rat prefrontal cortex. Eur.J Pharmacol 411:11-16S. Nudmamud, P. Siripurkpong, C. Chindaduangratana, P. Harnyuttanakorn, P. Lotrakul, W. Laarbboonsarp, A. Srikiatkhachorn, N. Kotchabhakdi, S. O. Casalotti (2000). Stress, anxiety and peripheral benzodiazepine receptor mRNA levels in human lymphocytes. Life Science 67, 2221-2231

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    Portfolio




    Module leader for BS4001 Biochemistry
    Module leader for BS5001 Biology of Disease

    Biomedical Science
    Biochemistry and Biotechnology

    Teaching