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Dr Abdessamad Ababou

Senior Lecturer in Biochemistry

Infection & Immunity Research Group                                                                                                                                                             School of , Health, Sport and Bioscience

    I am a Bioscientist with expertise in Protein Science (fold, stability, structure, dynamics, binding, design/engineering, kinetic processes, function, drug design, etc) using experimental and computational approaches. My main research methods/techniques are in the area of Structural Biology (NMR and X-ray crystallography. To view my protein structures click here and search my name), Molecular Biology, Biochemistry, Biophysics, Molecular Modeling, and Bioinformatics. In my recent/present research projects I am investigating the structure, assembly, export activity and drug design of several bacterial efflux pumps, which are becoming the most frequent drug resistance mechanism in bacteria. Bacterial drug resistance is a serious worldwide problem that causes death, great suffering, and high economic cost.

    Note that my research activities include several training aspects (academic and industrial) leading to bioscience/technical jobs for postgraduates (See details in Postgraduate Opportunities). For further details about my research group at UEL click here.

    I have a fully funded MRes position, the application deadline is 16 June 2019, which will start in September 2019For details click here.



    Postgraduate students (MRes and PhD) are welcome to apply and join my research group. All the proposed research projects will be done between UEL, King's College London, and Queen Mary University of London. For further details, please contact me for an informal discussion.

    At present, I have couple of new research projects in the theme of Bacterial Antibiotics Resistance, which are well imbedded within Biomedical and Pharmaceutical industries.

    These projects consist of several approaches/techniques in:

    * Structural Biology
    * Biochemistry
    * Drug Design (experimental and computational approaches)
    * Cell Biology (in vivo aspects).

     I have a fully funded MRes position offer, the application deadline is 16 June 2019, which will start in September 2019. For details click here.

    Member of Biochemical Society
    Member of Microbiology Society
    Fellow of HEA
    Visiting Senior Lecturer at KCL
    Reviewer for several journals
    Reviewer for funding agencies

    Overview


    My research interests focus on developing detailed understanding of the interactions between proteins and their ligand(s) in general (ligand = Protein, Peptide, DNA, RNA, small molecules, metals, etc), and in particular Protein-Protein Interactions, for Biomedical and Industrial Applications. My research goals are to design efficient and specific drugs for specific protein targets (Drug Design) and to design novel proteins for therapeutical and/or industrial purposes (Protein Design/Engineering).

    For further details about my research group at UEL click here.

    My present research projects consist of investigating the structure, assembly, export activity and drug design of several bacterial efflux pumps, which are becoming the most frequent drug resistance mechanism in bacteria. Bacterial drug resistance is a serious worldwide problem that causes death, great suffering, and high economic cost.

    Overall research themes:

    * Bacterial Multidrug Resistance (Drug Design Strategies)
    * Bacterial Efflux Pumps (Structure, Assembly & Export Mechanism)
    * Type 4 Secretion Systems in Gram-Positive Bacteria (Structure, Assembly & Activity Mechanism)

    Overall research work involves:

    * Cellular & Molecular Biology (Cloning, Mutagenesis, Protein Expression/Purification, In-vivo Assays, etc)
    * Protein/Protein-Ligand Structure, Dynamics & Function (Experimental & Computational Approaches)
    * Drug Design Strategies & Applications (Computational & Experimental Approaches)
    * Molecular Modelling (Structure, MD simulation, Binding & Stability Energetics, Biomolecular Interaction)
    * Bioinformatics (Data mining, Databases, scripting/programming)

    Collaborators

    • King's College London
    • Queen Mary University of London

    Research