Medicines Research Group (MRG)

Founded in 2007, the group has grown significantly over the years with research expertise including drug discovery and development.

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Founded in 2007, the group has grown significantly over the years with research expertise including drug discovery and development.

Medicines Research Group (MRG)

About us

Founded in 2007, the Medicines Research Group has grown significantly over the years with multidisciplinary research expertise in drug discovery and development, chemistry, phytochemistry, pharmacology, toxicology, microbiology and biopharmaceuticals. The group has developed strong collaborative links with many universities and research institutes within the UK and also internationally in China, India, Bangladesh, Brazil, Mexico, Nigeria and Ghana. In collaboration with our partners, we regularly host research meetings and symposiums and also have organised several international research workshops.

Key research staff

Dr Mukhlesur Rahman

Dr Mukhlesur Rahman (Research Group Lead) - Dr Rahman's main research area is natural product chemistry with particular focus on anti-infective drug discovery from medicinal plants, microbial cultures and marine organisms.

His research activities involve bioassay directed isolation, purification and identification of antibacterial and anticancer secondary metabolites from natural sources as well as the synthesis of their analogues to fit them for SAR study. Dr Rahman has been working on numerous medicinal plants from different parts of the world for the isolation and characterization of bio-active metabolites from a variety of structural classes including anti-MRSA compounds and efflux pump inhibitors (EPIs). In order to confirm the structures of the compounds of natural products, Dr Rahman exploits high field NMR (both 1D and 2D) spectroscopy and mass spectrometry. He collaborates with world-leading London universities and beyond.

Dr Winston Morgan

Dr Morgan's research interests are many and varied. His early research was in signal transduction in blood cells and the protein chemistry of auto-antibodies, he then moved on to liver and kidney toxicity. He is an experienced PhD supervision. Past students have been in areas as diverse as human placenta as an alternative to animals in toxicity testing, the role of probiotics and prebiotics in gut health and wound healing properties of certain Nigerian plants.  

He has an ongoing interest in the toxicity of Amphetamine related compounds. Recent projects include understand the long term toxicity of highly active antiretroviral therapy (HAART) in AIDS patients. His most recently completed PhD students worked on providing a better understanding of how Paracetamol and NSAID works in terms of anti-pyresis and anti-inflammation. His research has been informed by a knowledge of mechanistic toxicology, toxicity testing, pharmacology and clinical biochemistry.  A developing area of research and scholarly activity is the role of genes, race, and ethnicity in medical research a medical outcome for people described as Black Asian and Minority Ethnic (BAME).  Away from laboratory-based research Dr Morgan is involved in several learning and teaching projects looking at how to improve the student experience and performance of widening participation students and in particular those from BAME backgrounds. This work has led to Dr Morgan being invited to deliver several national keynote presentations.

Dr Stefano Casalotti

Dr Casalotti has investigated receptors systems (GABAa, Peripheral Benzodiazepine, NMDA, Opiate) at the protein and gene expression level, and studied the role of gap junctions in the auditory system. Currently his lab focuses on the cellular and molecular mechanisms that are affected by ethanol (alcohol) consumption.

The laboratory uses the Drosophila (fruit fly) model to study ethanol-induced behavioural changes including tolerance, preference and relapse. Cellular and molecular changes caused by alcohol consumption are analysed in both normal and genetically modified flies with the aim of understanding mechanisms that could play a role in human alcohol addiction.

Dr Casalotti is an honorary lecturer at UEL and director of BiosearLab, a Community Interest Company (CIC) based at UEL, focussed on promoting research collaborations with external organisations while providing training opportunities for UEL graduates.

Dr Samir Ayoub

Dr Samir Ayoub - Dr Ayoub's research focus has been on the pharmacology of paracetamol and the non-steroidal anti-inflammatory drugs in inflammation, pain and thermoregulation and has been the first to provide substantial evidence on implicating cyclooxygenase variant enzymes in mediating the thermoregulatory and analgesic actions of paracetamol. Dr Ayoub continues to be active in this area of research as well as in elucidating the role of interleukin-4 and cycloogenase-2 in the resolution of inflammation and macrophage polarisation. In recent years, Dr Ayoub has been collaborating with colleagues at the University of East London in research aimed at elucidation of mechanisms involved in the development of addiction behaviours to alcohol in Drosophila.

Dr Tummala Reddy

Dr Tummala Reddy - Dr Reddy has expertise of working on drug discovery projects involving rational drug design, synthesis and lead optimization of small molecules. His current research interests are in medicinal chemistry aspects of neglected tropical diseases and infectious diseases (antibacterial and antiviral). He uses various drug design strategies to understand how the structures of active derivatives of lead compounds/hit compounds interact with targeted receptors and guide the synthesis. Drug design strategies that are used in his lab for the compound design are structure-based drug design, Pharmacophore based drug design, Lead hopping, In-silico DMPK studies. He collaborates with partners in Brazil and Dundee.

Dr Hanieh Khalili

Dr Hanieh Khalili - Dr Khalili's research interests lie in the area of monoclonal antibody developments, in general, and with therapeutic applications, in particular. Her current research projects are focused on the development and formulation of the novel antibody-based mimetics for chronic diseases, such as ocular neovascularisation and uveitis, looking into ways of improving the sustained release profile with enhanced stability and extended duration of action. This translational research is crucial in developing next-generation biotherapeutics with great potential in the improvement of human health and well-being. This work will also benefit pharmaceutical companies (Big Pharma) involved in the biotherapeutic manufacturing and formulation.

Dr Barbara Pendry

Dr Barbara Pendry - Dr Pendry  is a Herbal Medicine Practitioner with a PhD in Phytotherapy involving the investigation of antioxidant activity in selected medicinal plants traditionally used in treating chronic age-related diseases. Her research interest in cancer and mental health patients has evolved from her previous work as a practitioner with Barnet Cancer Care and as a Mental Health Act Manager for a North London Mental Health Trust. She is Editor-in-Chief of the Journal of Herbal Medicine and serves on the Herbal Medicines Advisory Committee for the UK Government Agency MHRA and the Council Member of the European Herbal Traditional Practitioners Association.

Dr Eva Galante

Dr Eva Galante - Dr Galante's primary research interest lies in medicinal and green chemistry. Her expertise covers the design and pre-clinical evaluation of small molecules acting as chemotherapeutic agents. Currently, Dr Galante is interested in developing new protocols for the reduction of plastic waste generated in scientific laboratories.

Dr Geoff Webb

Dr Geoff Webb - Dr Webb  is an internationally renowned author (e.g. Dietary supplements and functional foods. Wiley/Blackwell 2012 and a book about weight control in Hodder’s famous "Teach Yourself" series). His earlier laboratory work focused on obesity in preclinical models. He has written extensively about many aspects of public especially the role of diet and lifestyle in health and disease. His more recent research has focused upon error and fraud in biological and medical research and a book about this aspect of his work is in press. He has maintained an active blog with posts about many aspects of nutrition, public health, biomedical research methodology. His blog contains many case studies of major research errors and fraudulent researchers.

Dr Bene Ekine-Afolabi

Dr Bene Ekine-Afolabi is a research associate in the HSB who graduated with a degree in Applied Biology (Medical Microbiology option) from River State University of Science & Technology, then an MRes degree from University of East London and PhD from Middlesex University. She also worked as associate lecturer at Biochemistry Department of Ladoke-Akintola University, Ogbomosho-Nigeria.

Trained in practical approach to toxicology in drug development (American College of Toxicology/British Toxicology Society), her research areas include Microbiology, Molecular Biology and Cancer Research. Her current focus of research is on the Investigation of molecular mechanism of colorectal cancer development, EMT, and cell death, as well as COVID-19. Bene was awarded part-sponsored training in High Impact Cancer Research & therapeutic and was awarded Distinction by Harvard University (Harvard Medical School). Their current project involves lead compound optimization in the development of novel therapeutic for colorectal cancer and COVID-19. She is Founder & CEO of  ZEAB Therapeutic LTD.

Daniel Ranson

Having previously completed clinical training as a Biomedical Scientist, Daniel Ranson is currently in the final stage of his PhD research in Behavioural Neuropsychopharmacology. His project explores the role of the GABAB receptor in modulating addiction like behaviours using Drosophila melanogaster. His research aims to understand the role of this neurotransmitter receptor behavioural, pharmacological and genetic tools to understand the role it plays in alcohol addiction.

Matthew Collins

Matthew is studying for a PhD at the University of East London. He is working on a project to develop hybrid strategies to generate bispecific antibody mimetics to counter angiogenesis and inflammation associated with disease. Prior to starting his PhD, Matthew worked in industry for approximately six years. He earnt an MSc in clinical drug development from Queen Mary University of London in 2017.

Oneza Saleem

Recently completed MRes in Phytochemistry and Cancer Research, Oneza has taken further her research findings onto a PhD. This project has focussed on the investigation of medicinal plants for isolation and identification of anticancer compounds. The research aims to screen medicinal plants against skin and breast cancer cell lines using cell viability assays followed by purification of active compounds from crude extracts by chromatographic methods like HPLC/ UPLC and their structure elucidation by spectroscopic methods like high field NMR techniques.

Hamid Kashkooli

Hamid is studying for a masters by research degree at the university of East London. Prior to this, he graduated with a first-class Honours degree in the Pharmaceutical Science. His current research focuses on encapsulating of recombinant fusion proteins such as Aflibercept within the fibril network of in-situ polymerizable collagen for sustained release. 

Journal, research and scholarly activities

The Group hosts the  Journal of Herbal Medicine, published by Elsevier, Germany. Dr Mukhlesur Rahman is a 'Guest editor' for 'Frontiers in Pharmacology' on the research topic 'Natural Products as Potential Therapeutics to Tackle Life-Threatening Infections: From Field to Market'.

Research and scholarly activity undertaken to date and work in progress is summarised under two broad areas of interest: 'ethnomedicine and drug discovery' and 'dietary supplements and functional foods'. 

Facilities

The Medicines Research Group possesses, or has access to cell culture, microbiology and proteomics facilities, analytical and preparative TLC and HPLC-UV, DAD, UPLC, LC-MS, GC-MS, AAS and FTIR spectroscopy, flow cytometry, DNA profiling facilities and nuclear magnetic resonance spectroscopy (NMR) via collaborations with University of London partners. 

Collaboration

The MRG has worked, or is working, in collaboration with: 

UK

International

Publications

Publications 2014- present

  1. Al‐Majmaie, S., Nahar, L., Rahman, M.M., Nath, S., Saha, P., Talukdar, A.D., Sharples, G.P. and Sarker, S.D. (2021) Anti‐MRSA    Constituents from Ruta chalepensis (Rutaceae) Grown in Iraq, and    In Silico Studies on Two Most Active Com‐Pounds, Chalepensin and   6‐Hydroxy‐Rutin 3’,7‐Dimethyl ether. Molecules 2021, 26, 1114. https://doi.org/10.3390/molecules26041114
  2. Shaik, A.B., Bhandare, R.R., Nissankararao, S., Lokesh, B.V.S., Shahanaaz, S. and Rahman, M.M. (2021) Synthesis, and biological screening of  chloropyrazine conjugated  benzothiazepine derivatives as potential  antimicrobial, antitubercular and cytotoxic agents, Arabian Journal of Chemistry, 14(2), 102915 DOI: https://doi.org/10.1016/j.arabjc.2020.102915
  3. Shaik, A.B.,Bhandare, R.R., Nissankararao, S., Edis, Z., Tangirala, N.R., Shahanaaz, S. and Rahman, M.M. (2020) Design, facile synthesis and characterization of dichloro substituted chalcones and dihydropyrazole derivatives for their antifungal, antitubercular and antiproliferative activities, Molecules, 25 (14), 3188; https://doi.org/10.3390/molecules25143188
  4. Cleal, M., Fontana, B.D., Ranson, D.C., McBride, S.D., Swinny, J.D., Redhead, E. and Parker, M.O. (2020). The Free Movement Patter Y-Maze: The Effective Study of Working Memory, Exploratory Patterns and Behavioural Plasticity. Behaviour Research Methods. Available at: doi.org/10.3758/s13428-020-01452-x.
  5. Santos, C.C., Batista, M.M., Ullah, A.I., Reddy, T.R.K. and Soeiro, M.N.C. (2020) "Drug screening using shape-based virtual screening and in vitro experimental models of cutaneous Leishmaniasis". Parasitology, 148 (1), 98 -104. https://doi.org/10.1017/S0031182020001900
  6. Anagani, B., Singh, J., Bassin, J.P., Besra, G.S., Benham, C., Reddy, T.R.K., Cox, J.A.G., Goyal, M. "Identification and validation of the mode of action of the chalcone antimycobacterial compounds'. 2020, The Cell Surface, 6, 100041.
  7. Bashir, S., Elegunde, B., Morgan, W.A. (2020) Inhibition of lipolysis: A novel explanation for the hypothermic actions of acetaminophen in non-febrile rodents. Biochem Pharmacol. 2:113774. doi: 10.1016/j.bcp.2019.113774.
  8. Adebola, O., Corcoran, O. and Morgan, W.(2020) Prebiotics may alter bile salt hydrolase activity: Possible implications for cholesterol metabolism. PharmaNutrition. 12 (Art. 100182). https://doi.org/10.1016/j.phanu.2020.100182
  9. Ayoub SS. Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action. Temperature (Austin). 2021 Mar 16;8(4):351-371. doi: 10.1080/23328940.2021.1886392. PMID: 34901318; PMCID: PMC8654482.
  10. Siddique, H., Pendry, B., and Rahman, M.M., (2019) Terpenes from  Zingiber montanum  and their screening against multi-Drug resistant and methicillin resistant Staphylococcus aureus, Molecules, 24 (3), 385;  https://doi.org/10.3390/molecules24030385
  11. Aleyakpo, B., Umukoro, O., Kavlie, R., Ranson, D.C., Thompsett, A., Corcoran, O. and Casalotti, S.O. (2019). G-Protein aq gene expression plays a role in alcohol tolerance in Drosophila melanogaster. Brain and Neuroscience Advances. 3(1). Available at: doi.org/10.1177/2398212819883081.
  12. Ranson, D.C., Ayoub, S.S., Corcoran, O. and Casalotti, S.O. (2019). Pharmacological targeting of the GABAB receptor alters Drosophila’s behavioural responses to alcohol. Addiction Biology. 25(2). Available at: doi.org/10.1111/adb.12725. 
  13. Kougiali ZG, Soar K , Pytlik A , Brown J , Wozniak K , Nsumba F , Wilkins T, Oliva E , Osunsanya S, Clarke C, Casalotti SO and Pendry B. (2019) Jigsaw Recovery: The Spatio-temporalities of Alcohol Abuse and Recovery in a Non-interventionist, Peer-led Service. Alcoholism Treatment Quarterly epublication https://doi.org/10.1080/07347324.2019.1686960
  14. Ayoub, S.S. and Flower, R.J. (2019) Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes. Eur J Pharmacol. 861:172609. doi: 10.1016/j.ejphar.2019.172609.
  15. Rahman, M.M., Shiu, W. K. P., Malkinson, J. P., Gibbons, S. (2018) Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus, European Journal of Medicinal Chemistry 155, 255-262.
  16. Tareq, F.S., Hasan, C.M., Rahman, M.M., Hanafi, M.M.M., Spiteller, P. (2018) Anti-staphylococcal Calopins from a wild mushroom, Boletus radicans, Journal of Natural Products, 81 (2), 400–404.
  17. Danquah, C.A., Kakagianni, E., Khondkar, P., Maitra, A., Rahman, M.M, Evangelopoulos, D., McHugh,T.D., Stapleton, P., Bhakta, S. and Gibbons, S. (2018) Analogues of natural product disulfides from Allium stipitatum demonstrate potent anti-tubercular activities through drug efflux pump and biofilm inhibition, Scientific Reports 8, 1150.
  18. Nurunnabi, T., Nahar, L., Al-Makmaie, S., Rahman, S.M.M., Sohrab, M.H., Billah, M.M., Ismail, F.M.D., Rahman, M.M., Sharples, G,P. and Sarker, S.D. (2018) Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes, Phytotherapy Research, 32 (2), 348-352.
  19. Peres, R. B., Ullah, A.I., Almeida Fiuza, L.F.A., Silva, P.B., Batista, M.M., Corcoran, O., Reddy, T.R.K. and Soeiro, M.N.C. (2018). "Identification and Preliminary Structure-Activity Relationship Studies of Novel Pyridyl Sulfonamides as Potential Chagas Disease Therapeutic Agents". Bioorganic & Medicinal Chemistry Letters, 28, 2018-2022.
  20. Fiuza, L.F.A., Peres, R B., Simões- Silva, M. R., da Silva, P. B., Batista, D. G. J., da Silva, C. F., da Gama, A. N. S., Reddy, T. R. K., Soeiro, M. N. C. (2018) "Identification of Pyrazolo[3,4-e][1,4] thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration", European Journal of Medicinal Chemistry, 149, 257-268.
  21. Koyyada, R., Latchooman, N., Jonaitis, J., Ayoub, S.S., Corcoran, O., Casalotti, S.O. Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster. Front Physiol. 2018; 9:175. doi: 10.3389/fphys.2018.00175.
  22. Milovanova-Palmer, J., Pendry, P. (2018) Is there a role for herbal medicine in the treatment and management of periodontal disease? Journal of Herbal Medicine, 12, 33-48
  23. Pendry, P., Kemp, V., Hughes, M J., Freeman, J., Corcoran, O, Galante, E. (2017) Silymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tinctures. Journal of Herbal Medicine Volume 10, Pages 31-36
  24. Büttner, S., Beer, A-M, Pendry, B. (2017) The Potential Role of Phytotherapy as a Supportive Treatment in Breast Cancer Patients. Deutsche Zeitschrift für Onkologie 49(03):124-128.
  25. Sharma CV, Long JH, Shah S, Rahman J, Perrett D, Ayoub SS, Mehta V. (2017) First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid. J Pain Res. 10, 2703-2709. doi: 10.2147/JPR.S143500.
  26. Mundy, L., Pendry, B. and Rahman, M. M. (2016) Antimicrobial resistance and synergy in herbal medicine, Journal of Herbal Medicine, 6(2), 53–58.
  27. Prosen, H., Pendry, B. (2016) Determination of shelf life of Chelidonium majus, Sambucus nigra, Thymus vulgaris and Thymus serpyllum herbal tinctures by various stability-indicating tests. Phytochemistry Letters 16:311-323
  28. Wright, V., Pendry, B. (2016) Compassion and its role in the clinical encounter – An argument for compassion training Journal of Herbal Medicine 6(4), Pages 198-203
  29. Rahman, M. M. and Gibbons, S. (2015) Antibacterial constituents of Neohyptis paniculata, Fitoterapia 105, 269-272.
  30. Pesewu, G.A., Culter, R.R., Humber, D.P., Morgan, W.A. (2015) Evaluation of Antibacterial Activity and Phytoconstituents of the Aqueous Leaves Extract of Alchornea Cordifolia, International Scientific Research Journal, 1(07), pp. 48-54. DOI: 10.18483/IRJSci.54
  31. Sander, K.,Galante, E., Gendron, T., Yiannaki, E., Patel, N., Kalber, T.L.,Badar, A., Robson, M., Johnson, S.P., Bauer, F., Mairinger, S., Stanek, J., Wanek, T., Kuntner, C., Kottke, T., Weizel, L., Dickens, D., Erlandsson, K., Hutton, B.F., Lythgoe, M.F., Stark, H., Langer, O., Koepp, M., Årstad, E. (2015) Development of fluorine-18 labelled metabolically activated tracers for imaging of drug efflux transporters with PET. J. Med. Chem. 2015, 58, 6058 – 6080.
  32. Della, Peruta. M., Badar, A., Rosales, C., Chokshi, S., Kia, A., Nathwani, D., Galante, E., Yan, R., Arstad, E., Davidoff, A.M., Williams, R., Lythgoe, M.F., Nathwani, A.C.  Preferential targeting of disseminated liver tumors using a recombinant adeno-associated viral vector. Hum. Gene Ther. 2015, 26, 94 - 103.
  33. Galante, E., Okamura, T., Sander, K., Kikuchi, T., Okada, M., Zhang, M.R., Robson, M., Badar, A., Lythgoe, M., Koepp, M., Årstad, E. (2014) Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET. J. Med. Chem. 2014, 57, 1023 - 1032.
  34. Adebola, O.O., Corcoran, O., Morgan, W.A. (2014) Synbiotics: the impact of potential prebiotics inulin, lactulose and lactobionic acid on the survival and growth of lactobacilli probiotics. Journal of Functional Foods, 10, 75-84.
  35. Xia, H., Sun, L., Lou, H. and Rahman, M. M. (2014) Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity, Phytomedicine 21(6), 906-11.
  36. Rooney, S., Pendry, B. (2014) Phytotherapy for Polycystic Ovarian Syndrome: A review of the literature and evaluation of practitioners’ experiences. Journal of Herbal Medicine vol 4 (3) pp 159-171.
  37. Ekine-Afolabi, B. et al., (2020) The impact of diet on the involvement of non-coding RNAs, extracellular vesicles and gut microbiome-virome in colorectal cancer initiation and progression, Front. Oncol. | doi: 10.3389/fonc.2020.583372
  38. Elbehi, A. M., Anu, R. I., Ekine-Afolabi, B., Cash, E., (2020) Emerging role of immune checkpoint inhibitors and predictive biomarkers in head and neck cancers Elsevier https://doi.org/10.1016/j.oraloncology.2020.104977.
  39. Anu, R. I., Elbehi, A. M., Ekine-Afolabi, B., Cash, E., (2020). Mutational signatures, variant to topography, and signalling pathways in breast cancer: a futuristic approach to personalized care. translational genomic doi:10.9777/tg.2020.10001

Books and book chapters

  •  
  • Webb, G.P. (2021) Error and Fraud: the Dark Side of Biomedical Research. CRC Press (Taylor and Francis group): Boca Raton, Fl.
  • Webb, G.P. (2019) Nutrition: maintaining and improving health. 5th edition. CRC Press (Taylor and Francis group): Boca Raton, Fl.
  • Rahman, M. M. and Sarker, S. D. (2020) Chapter Three - Antimicrobial natural products. In: Sarker, S. D. and Nahar, L. (eds), Annual reports in Medicinal Chemistry: Amsterdam, Oxford and, Waltham: Elsevier, Vol. 55, Chapter 3, pp 77-113. ISBN: 978-0-12-821019-2.
  • Webb, G.P. (2019) Dietary supplements: A Classification and Overview of Uses and Efficacy. In Worsfold, P., Poole, C., Townshend, A., Miro, M., (Eds), Encyclopaedia of Analytical Science, (3rd ed.). vol 3. pp 4016-418.  Elsevier.
  • Rahman, M. M. (2018) Application of computational methods in isolation of plant secondary metabolites. In: Sarker, S. D. and Nahar, L. (eds), Computational Phytochemistry: Amsterdam, Oxford and, Waltham: Elsevier, Chapter 4, pp 107-139. ISBN: 9780128123645.
  • Rahman, M. M. (2014) Antimicrobial secondary metabolites- extraction, isolation, identification and bioassay. In: Mukherjee, P. K. (ed), Evidence-Based Validation of Herbal Medicine: Amsterdam, Oxford and, Waltham: Elsevier, pp 495-513. ISBN: 9780128008744.
  • Webb, GP (2015) Vitamins/minerals as dietary supplements: a review of clinical studies. In Dietary supplements Ed Berginc, K and Kreft, S. Oxford: Woodhead Publishing. pp 139-169.
  •  

Conference Papers (2014-Present)

  •  
  • Ranson, D.C., Ayoub, S.A., Corcoran, O. and Casalotti, S.O. (2021) "The GABAb receptor is involved in the development of ethanol seeking behaviours" British Neuroscience Association bi-annual meeting. Online
  • Ranson, D.C., Ayoub, S.A., Corcoran, O. and Casalotti, S.O. (2019) "Drosophila models for studying the role of GABA and its receptors in alcohol-induced behaviours." British Neuroscience Association bi-annual meeting. Dublin Ireland
  • Khalili, H. et al (2019) "Stability studies of anti-VEGF FpFs obtained from bevacizumab digested with different enzymes" Poster presented in American Association of Pharmaceutical Scientist (AAPS) Annual Meeting, San Antonio, USA, 2019.
  • Khalili, H. et al (2019) "Thermodynamic properties of anti-VEGF F antibody mimetic in the solution" Poster accepted to be presented in Control Release Society (CRS) Annual Meeting, Spain, July 2019.
  • Khalili, H. et al (2019) "Lyophilisation of an anti-VEGF antibody mimetic to make a solid implant"  Poster accepted to be presented in Control Release Society (CRS) Annual Meeting, Spain, July 2019.
  • Khalili, H. et al (2019)  "Binding characterization of bispecific antibody mimetics'  Poster accepted to be presented in Control Release Society (CRS) Annual Meeting, Spain, July 2019.
  • Bajwa, P., Garrido Mesa, N., Seed, M. and Ayoub, SS. (2019) Effects of heparan sulfates with different structures on leukaemia cells: U937 and THP-1 cell differentiation. 14th World Congress on Inflammation 2019. Sydney, AU 15 - 19 Sep 2019 World Congress on Inflammation.
  • Bajwa, P., Garrido Mesa, N., Seed, M. and Ayoub, SS. (2019) Sucrose octasulphate regulates the expression of M1 and M2 macrophage-specific markers in U937 monocytes. 14th World Congress on Inflammation 2019. Sydney, AU 15 - 19 Sep 2019 World Congress on Inflammation.
  • Rahman, M. M. (2018) 'Zingiber montanum: from an ethnopharmacological survey to the bioassay directed identification of secondary metabolites'. Delivered a keynote lecture in the Phytochemical Society of Europe’s conference on ‘Advances in Phytochemical Analysis (Trends in Natural Products Research)’ held in Liverpool on July 2-5, 2018.
  • Rahman, M. M. (2018) 'Anti-infective medicinal plants of Bangladesh-an ethnopharmacological survey, chemistry and bioassay'.  Delivered a lecture in the 18th International Congress of the International Society for Ethnopharmacology jointly with the Society for Ethnopharmacology India held on January 13-15, 2018 in the University of Dhaka, Bangladesh.
  • Siddique, H., Pendry, B., and Rahman, M. M, (2018) Antibacterial mono- and sesqui-terpenes from Zingiber montanum; A poster presented in the Phytochemical Society of Europe conference’s on 'Advances in Phytochemical Analysis (Trends in Natural Products Research)' held in Liverpool on July 2-5, 2018.
  • Ranson, D.C., Ayoub, S.A., Corcoran, O. and Casalotti, S.O. (2018) "Targeting of the GABAB receptor alters the development of cue induced preference to ethanol in Drosophila". British Pharmacological Society, Edinburgh, Scotland.
  • Ranson, D.C., Ayoub, S.A., Corcoran, O. and Casalotti, S.O. (2018) "Pharmacological modulation of ethanol responses via GABA-B receptors in Drosophila melanogaster". FENS meeting Berlin Germany.
  • Ranson, D.C., Ayoub, S.A., Corcoran, O. and Casalotti, S.O. (2018) "Drosophila Sensitivity and Tolerance to Ethanol is Altered by GABAB Receptor Drugs".  British Pharmacological Society, London, England
  • Siddique, H., Pendry, B., Tocher, J., and Rahman, M. M, (2017) Anti-infective medicinal plants- an ethnopharmacological survey in Bangladesh. Both podium and poster presented at the APSGB 8th International PharmSci Conference 2017 in the University of Hertfordshire on September 5-7, 2017.
  • Aleyakpo, B., Kavlie, R., Umukoro, O., Ranson, D., Corcoran, O., Casalotti, S.2017  "Down regulation of G proteins affects tolerance to alcohol in Drosophila melanogaster" British Neuroscience Association bi-annual meeting. Birmingham UK
  • Khalili, H. "Antibody mimetic; A better antibody-based medicine" Invited plenary speaker at Pharmaceutical Drug Delivery System, Spain, 2017.
  • Deshai, Devyani and Ayoub, SS. The perception of Pharmacology among undergraduate students at the University of East London. Pharmacology 2017. London, UK 11 - 13 Dec 2017, British Pharmacological Society
  • Manoj, Sivanjaa, Morgan, W. and Ayoub, SS. The requirement of p38-MAPKinase and peroxisome proliferator-activated receptor-g for the induction of cyclooxygenase-2 by interleukin-4 drives macrophages into an anti-inflammatory phenotype. Pharmacology 2017, London, UK 11 - 13 Dec 2017, British Pharmacological Society.
  • Rahman, M. M. (2016) 'Antibiotics resistance and plant derived secondary metabolites'. Delivered a lecture in the during the 7th World Ayurveda Congress & AROGYA Expo (7th WAC) on 'Ethnopharmacology, Ethnomedicine and Traditional Health Practices' held on 3-4 December 2016 at Science City, Kolkata, India.
  • Sivanjaa Manoj, Manoj, Morgan, W. and Ayoub, SS. Characterisation of the signalling mechanisms involved in the induction of cyclooxygenase-2 by interleukin-4. PHARMACOLOGY 2016. London 13 - 15 Dec 2016, British Pharmacological Society.
  • Khalili, H. et al: "Storage stability studies of anti-VEGF FpF antibody mimetics" Poster in American Association of Pharmaceutical Scientist (AAPS) Annual Meeting, Denver, USA, 2016.
  • Khalili, H. "Bispecific cytokine antibody mimetics for vascular disease" Invited speaker in an international workshop on cardiovascular biology and translational medicine, Royal College of Physicians, London, UK, 2016.
  • Khalili, H. Invited to run a workshop on "Therapeutic antibodies; Fundamental, Efficacy, and Stability", AryoGen Pharmed Co. Tehran, Iran, 2016.
  • Aleyakpo, B., Kavlie, R., Umukoro, O., Ranson, D., Corcoran, O., Casalotti, S. 2016 'Knock-down of G protein expression alters alcohol-induced behaviour in Drosophila Melanogaster" British Pharmacological Society, London, England
  • Rahman, M. M. (2015) 'Plant derived new antibacterial secondary metabolites- isolation, identification and total synthesis'.  Delivered a lecture in the ‘CHEMRAWN XX -20th IUPAC conference on Chemical Research Applied to World Needs’ held on November 06-09, 2015, Dhaka, Bangladesh.
  • Rahman, M. M. (2015) 'Plant derived secondary metabolites against multi-drug resistant (MDR) and methicillin resistant Staphylococcus aureus (MRSA)'. Invited as a special guest and delivered a plenary lecture in the 19thAnnual Convention and 2ndInternational Conference of the Society of Pharmacognosy held on March 20- 22, 2015 in Andhra University, India.
  • Umukoro, O.,Corcoran, O., Stefano Casalotti, S. 2015 "Ethanol-induced G-protein subunit expression changes in D2 receptor deficient Drosophila" British Neuroscience Association bi-annual meeting. Edinburgh, Scotland
  • Rahman, M. M., Shiu, W. K. P., Gibbons, S. and Malkinson, J. P. (2015) Synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of MRSA strains. Poster presented at the ASP2015 meeting held in Copper Mountain, Colorado, USA on July 25 - 29, 2015; Abstract published in Planta Medica 81(11): PZ1.
  • Khalili, H. "Antibody mimetic" Invited speaker in MedImmune KTN formulation meeting, Cambridge, UK, 2015.
  • Khalili, H. "Ocular inflammation; Infliximab antibody mimetic" Podium in Inflammation and Immunity symposium, London, UK, 2015.
  • Khalili, H. et al: "Novel anti-TNF-a antibody mimetic to treat ocular inflammation" Poster in UCL Infection and Inflammation immunity forum, London, 2015.
  • Khalili, H.et al: "The increased stability of FpFs compared to monoclonal antibodies" Poster in Association for Research in Vision and Ophthalmology (ARVO), Denver, USA, May 2015
  • Ayoub SS, Cooper C, Nunes F and Ruocco R. Construction of cell models for drug-receptor pharmacology activities for schools outreach: Generating awareness and interest in pharmacology in the younger generations. British Pharmacological Society Conference, 15-17  Dec 2015, London, UK 
  • Rahman, M. M. (2014) 'Antibacterial secondary metabolites from indigenous medicinal plants'. A plenary lecture in 1st International Congress of the Society for Ethnopharmacology (ICSE 2014) on "Globalizing Traditional Medicine: present and Future Prospects" held in Sri Ramachandra University, Chennai, India on March 07-09, 2014.
  • Khalili, H. et al: "Novel anti-TNF-α Fab-PEG-Fab for ocular inflammation" Poster in Association for Research in Vision and Ophthalmology (ARVO), Orlando, USA, May 2014.
  • Sharma, G., Khalili, S. Brocchini, S., P. T. Khaw, "Co- culture of Human Tenon Fibroblast and macrophages as a novel in-vitro model for conjunctival scarring", Poster in Association for Research in Vision and Ophthalmology (ARVO), Orlando, USA, May 2014
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Other online articles

Links to other online articles by Dr Geoff Webb:

Links to other online articles by Dr Winston Morgan:

 

Contact us

General enquiries to the Medicines Research Group can be made to  Dr Rahman at the Stratford Campus: 

Dr Mukhlesur Rahman
Tel: +44 (0) 208 223 4299
Email:  m.rahman@uel.ac.uk

University of East London, Stratford Campus 
Romford Road 
London 
E15 4LZ