Dr Tummala Reddy
Senior Lecturer
Medicinal Chemistry
Department of Bioscience , School Of Health, Sport And Bioscience
Dr Reddy is a Senior Lecturer in Medicinal Chemistry, Programme Leader of MSc Pharmaceutical Science and a member of the Medicines Research Group.
Qualifications
- PhD, M.Phil, M.Pharm
Areas Of Interest
- Rational design and synthesis of novel therapeutics for the treatment of methicillin-resistant staphylococcus aureus infections
- Design and development of potential drug candidates for the treatment of Chagas disease
- Kinetic solubility assays for drug-like molecules
OVERVIEW
Dr Reddy is a Senior Lecturer in Medicinal Chemistry, Programme Leader of MSc Pharmaceutical Science and a member of the Medicines Research Group. He has previously worked as a Lecturer in Medicinal chemistry at the Department of Pharmacy, University of Hertfordshire (2012 to 2015) and as a postdoctoral research fellow in Medicinal chemistry and Drug design at the University of Nottingham for over 5 years. This project was funded by Cancer Research UK.
Dr Reddy obtained his PhD in Medicinal Chemistry at the University of Sheffield, funded by the Department of Health, UK. M.Phil (research) in Computational drug design at the University of Nottingham and M.Pharm in Pharmaceutical Chemistry at the IIT, BHU (India) funded by the University Grants Commission (UGC), India. He worked as a formulation chemist at Alkem laboratories, Daman (India), after his M.Pharm.
CURRENT RESEARCH
Dr Reddy has expertise in working on drug discovery projects involving rational drug design, synthesis and lead optimisation of small molecules.
His current research interests are in medicinal chemistry aspects of neglected tropical diseases.
Dr Reddy uses various drug design strategies to understand how the structures of active derivatives of lead compounds/hit compounds interact with targeted receptors and guide the synthesis. Various drug design strategies that are used in his lab for the compound design are structure-based drug design, pharmacophore-based drug design, Lead hopping, and In-silico DMPK studies.
PhD completions:
- Dr Asma Inam Ullah (February 2016 -January 2020): Currently working (part-time) as a Lecturer at Coventry University
Reviewer of the following journals:
- Bioorganic & Medicinal Chemistry Letters
- Journal of Antimicrobial Chemotherapy
- Antimicrobial Agents and Chemotherapy
PUBLICATIONS
- Drug screening using shape-based virtual screening and in vitro experimental models of cutaneous Leishmaniasis, Camila Cardoso Santos, Marcos Meuser Batista, Asma Inam Ullah, Tummala Rama Krishna Reddy and Maria de Nazaré Correia Soeiro. Parasitology, Volume 148, Issue 1, January 2021, pp. 98 - 104.
- Identification and validation of the mode of action of the chalcone antimycobacterial compounds.B. Anagani, J. Singh, J.P. Bassin, G.S. Besra, C. Benham, T.R.K. Reddy, J.A.G. Cox, M. Goyal.. 2020. The Cell Surface. 6, 100041.
- Identification and Preliminary Structure-Activity Relationship Studies of Novel Pyridyl Sulfonamides as Potential Chagas Disease Therapeutic Agents
- Raiza Brandão Peres, Asma Inam Ullah, Ludmila Ferreira de Almeida Fiuza, Patricia Bernardino Silva, Marcos M Batista, Olivia Corcoran, Tummala Rama Krishna Reddy, and Maria de Nazaré Correia Soeiro.. 2018. Bioorganic & Medicinal Chemistry Letters. 28, 2018-2022.
- Identification of Pyrazolo[3,4-e][1,4] thiazepin-based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration
- Ludmila Ferreira de Almeida Fiuza, Raiza Brandão Peres, Marianne Rocha Simões- Silva, Patricia Bernardino da Silva, Denise da Gama Jaen Batista, Cristiane França da Silva, Aline Nefertiti Silva da Gama, Tummala Rama Krishna Reddy, Maria de Nazaré Correia Soeiro. 2018. European Journal of Medicinal Chemistry. 149, 257-268..
- Design, Synthesis and SAR Exploration of Trisubstituted 1,2,4-Triazoles as Potential Inhibitors of the Annexin A2-S100A10 Protein Interaction Reddy, T., Li, C., Guo, X., Fischer, P., Dekker, L.. 2014. Bioorganic & Medicinal Chemistry. 5378-5391.
- Three-Dimensional Pharmacophore Design and Biological Screening Identifies Substituted1,2,4-Triazole Compounds as Inhibitors of the Annexin A2-S100A10 Protein Interaction. Reddy, T., Li, C., Fischer, P., Dekker, L.. 2012. ChemMedChem. 1435-1446.
- Design, Synthesis, and SAR Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogue as Inhibitors of the Annexin A2–S100A10 Protein Interaction Reddy, T., Li, C., Guo, X., Myrvang, H., Fischer, P., Dekker, L.. 2011. Journal of Medicinal Chemistry. 2080-2094.
- Patent: Preparation of pyrrole derivatives as S100 protein binding interaction inhibitors for the treatment of cancer and other diseases, Reddy, T., Li, C., Fischer, P., Dekker, L.. 2011. Patent application has been filed by the Cancer Research Technology Limited (UK), Patent No. WO2011092505.
- Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin A2Li, C., Reddy, T., Fischer, P., Dekker, L.. 2010. Assay and Drug Development Technology. 85-95.
- Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction: potential anti-angiogenesis therapeutics.
- Reddy, T., Li, C., Guo, X., Fischer, P., Dekker, L.. 2010. Journal of Pharmacy and Pharmacology. 1373-1374. Synthesis and Evaluation of a Focused Library of Pyridine Dicarbonitriles Against Prion Disease.
- Guo, K., Mutter, R., Heal, W., Reddy, T., Cope, H., Pratt, S., Thompson, M., Chen, B. 2008. European Journal of Medicinal Chemistry. 93-106.
- Mechanistic studies lead to a new procedure for rapid microwave-assisted generation of pyridine-3,5-carbonitride libraries. Guo, X., Thompson, M.J., Reddy, TRK., Mutter, R., Chen, B.. 2007. Tetrahedron. 63 (24) 5300-5311.
- Library Design, Synthesis and Screening: Pyridine Dicarbonitriles as Potential Prion Disease Therapeutics L. Reddy, TRK., Mutter, R., Heal, W., Guo, K., Gillet, V.J., Pratt, S., Chen, B.. 2006. Journal of Medicinal Chemistry. 49(2), 607-615.
TEACHING
BSc (Hons) Biomedical Science
Biomedical scientists are key players in the modern healthcare system. At UEL, you will study the causes of disease and the practical ways they can be investigated in the laboratory.
Study BSc Biomedical Science
BSc (Hons) Chemistry
Earn your Chemistry degree at UEL. Explore the fundamentals of chemical reactions, materials, and processes. Develop analytical and lab skills for diverse science careers.
Study BSc Chemistry
BSc (Hons) Pharmaceutical Science
Study Pharmaceutical Science degree at UEL: Explore drug development, formulation, and quality control. Gain essential skills for a career in the pharmaceutical industry.
Study BSc Pharmaceutical Science
MSc Pharmaceutical Science (with specialism)
Get a detailed understanding of pharmaceutical science and develop the skills needed for individual and collaborative research in drug development.
Study MSc Pharmaceutical ScienceMODULES
- Foundation course: Chemistry of Life
- Level 4: Essential Chemistry
- Level 4: Fundamentals of Analytical Chemistry
- Level 5: Pharmaceutics and Drug Delivery
- Level 6: Pharmaceutical Analysis and Instrumentation
- Level 6: Natural Product Chemistry and Drug Design
- Level 7: Drug Discovery, Design and Development
- Level 7: Advanced Pharmaceutical Analysis & Quality Control
Publications
The last four years of publications can be viewed below.
Full publications list
Visit the research repository to view a full list of publications
- Drug screening using shape-based virtual screening and in vitro experimental models of cutaneous Leishmaniasis Parasitology. 148 (1), p. 98–104. https://doi.org/10.1017/S0031182020001900
- Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds The Cell Surface. 6 (Art. 100041). https://doi.org/10.1016/j.tcsw.2020.100041
- Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration European Journal of Medicinal Chemistry. 149, pp. 257-268. https://doi.org/10.1016/j.ejmech.2018.02.020
- Identification and preliminary structure-activity relationship studies of novel pyridyl sulfonamides as potential Chagas disease therapeutic agents Bioorganic & Medicinal Chemistry Letters. 28 (11), pp. 2018-2022. https://doi.org/10.1016/j.bmcl.2018.04.064