Dr Samir Shawgy Ayoub
Senior Lecturer
Medicines Research Group
Department of Bioscience , School of Health Sport and Bioscience
Dr Samir Ayoub is a valued member of the pharmacology programme and modules leadership, helping to widen participation and promotion of pharmacology within the further education community. He is also a supervisor of PhD and MSc students.
Areas Of Interest
- Member of the editorial board for Inflammopharmacology
- Active member of the British Pharmacological Society
- Ambassador for the British Pharmacological Society
OVERVIEW
Dr Ayoub is a senior lecturer in pharmacology at the University of East London.
He completed his PhD at the William Harvey Research Institute in London. Following this, he was awarded a Leverhulme Trust Early Career Fellowship, which included a period as a visiting scientist in Professor Daniel Simmons' laboratory at Brigham Young University in the USA.
Before joining the University of East London, Dr Ayoub worked as a research associate at the Institute of Heart and Lung, Imperial College London.
CURRENT RESEARCH
Dr Ayoub's research has focused on the pharmacology of paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) in the context of inflammation, pain, and thermoregulation. He was the first to provide significant evidence that cyclooxygenase (COX) variant enzymes mediate the thermoregulatory and analgesic effects of paracetamol.
He continues to be active in this field, working to understand the role of interleukin-4 and cyclooxygenase-2 in resolving inflammation and macrophage polarisation.
In recent years, he has also collaborated with UEL colleagues on research aimed at clarifying the mechanisms behind the development of alcohol addiction behaviours in Drosophila (fruit flies).
FUNDING
| Funding awarded | Total funding amount |
|---|---|
| QR funding by the University of East London to survey study on the perception of further education students on pharmacology. February 2019 | £904.35 |
| QR Fund by the University of East London. Mini-sabbatical (1 term) for teaching cover to spend time writing research papers. January 2018 | £990 |
| Funding for Bioscience Research Conference by ReDS, July 2013 | £1729.25 |
| Research and Knowledge Exchange Grant funded by School of Health, Sport and Bioscience, to fund research project aimed at further characterization of human macrophage cell line, February 2013 | £7173.26 |
| Research Development fund by ReDS, Further characterization of the diclofenac induced cyclooxygenase-2 protein, March 2012 | £5000 |
| Funding for PhD studentship by School of Health, Sport and Bioscience, "An investigation into the role of novel cyclooxygenase variant proteins in inflammation", January 2012, | £63,912 |
| Funding by School of Health, Sport and Bioscience to present at the European Workshop on Lipid Mediators, Paris, 27-28 Sept 2012 | £600 |
| Cyclooxygenase variants in temperature regulation. Early Career Fellowship. The Leverhulme Trust. Oct 06-Oct 08 *This award was announced in the Times Newspaper (Friday 15 September 2006, page 66) | £38,961 |
Pharmacology at the University of East London
Studying pharmacology at the University of East London alongside our prize-winning, internationally recognised lecturers gives you access to excellent research and work opportunities so you leave ready to make an impact and #BeTheChange through your career.
MODULES
- Level 4: Professional Practice in Science
- Level 5: Fundamental & Experimental Pharmacology (module leader)
- Level 5: Drug Discovery, Development and Regulations (module leader)
- Level 5: Research and Career Development
- Level 6: Neuropsychopharmacology and Emerging Therapeutics (module leader)
- Level 6: Immunopharmacology and Chemotherapeutics (module leader)
- Level 6: Cardiovascular and Pulmonary Pharmacology
- Level 6: Toxicology
- Level 6: Research Project and Career Enhancement Portfolio
- Level 7: Advanced Techniques in Bioscience
- Level 7: MSc Research Project
PUBLICATIONS
Visit the UEL research repository to view a full list of publications.
Publications
Browse past publications by year.
Full publications list
Visit the research repository to view a full list of publications
- Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action Temperature. 8 (4), pp. 351-371. https://doi.org/10.1080/23328940.2021.1886392
- Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes European Journal of Pharmacology. 861 (Art. 172609). https://doi.org/10.1016/j.ejphar.2019.172609
- Pharmacological targeting of the GABAʙ receptor alters Drosophila's behavioural responses to alcohol Addiction Biology. 25 (Art. e12725). https://doi.org/10.1111/adb.12725
- Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster Frontiers in Physiology. 9 (175), pp. 1-7. https://doi.org/10.3389/fphys.2018.00175
- First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid Journal of Pain Research. 10, pp. 2703-2709. https://doi.org/10.2147/JPR.S143500
- Role of GABAB receptors in ethanol induced behaviours pA2 Online: Proceedings of the British Pharmacological Society. 18 (1)
