Current PhD student; Alexander Lyons (email@example.com)
Poster presentation: The Metabolic Profiling of Exercise Intervention: Exercise Metabolomics
Biomedical basis of elite performance conference, Queen Elizabeth II conference centre London UK March 2012
Exercise stress induces change in muscle biochemistry to meet the metabolic demands of the working muscles (1). Such change can be observed directly from the presence of biomarkers elucidated from change in protein and metabolite profiles, lightweight molecular products of metabolism, in muscle cells(2) and biofluids(3). The majority of previous research in the biochemical monitoring of sport and exercise has relied on observing change in targeted (pre-selected) metabolites, which provides a modest amount of data on metabolic change.
Advances in bioanalytical technology presents metabolomic techniques as effective tools to provide multidimensional data of all metabolite profiles in minute biological samples(4), which has unprecedented potential to monitor exercise-induced biochemical change. Metabolomic techniques include gass/liquid chromatography-mass spectrometry (GC/LC-MS) and nuclear magnetic resonance spectroscopy (NMR). In order to establish current status of this research area, a literature search was carried out and presented in this poster
Objective and expected outcomes/benefits for this PhD research
To develop metabolomic protocols to profile change in blood, urinary and salivary metabolites induced by isolated muscle contractions. The aim is to establish reliable protocols to standardise the identification of biomarkers allied to sport, exercise and rehabilitation.
The expected outcome/benefit of this PhD programme of research is that it will contribute to the future design of biochemical monitoring in sport, exercise and rehabilitation.
- Whyte, J.J. and Laughlin, M.H. (2010) The effects of acute and chronic exercise on the vasculature. Acta Physiol, 199:441-450
- Green, H.J., Bombardier, E., Burnett, M.E., Smith, I.C., Tupling, S.M., and Ranney, D.A. (2009) Time-dependent effects of short term training on muscle metabolism during early phase of exercise. Am J Physiol Regul Interg Comp Physiol, 297:1318-1391
- Neary, J.P., Malbon, L. and McKenzie, D.C. (2002) Relationship Between Serum, Saliva and Urinary Cortisol and its Implication During Recovery from Training. Journal of Science and Medicine in Sport, 5(2):108-114
- Corcoran, O. and Spraul, M. (2003) LC-NMR-MS in drug discovery. Drug Discovery Today, 8:624-631
- Papacosta, E. and Nassis, G.P. (2011) Saliva as a tool for monitoring steroid, peptide and immune markers in sport and exercise science. Journal of Science and Medicine in Sport, 14:424-434.