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Dr Morgan, Winston

Contact details

Position: Principal Lecturer

Location: AE5.19, Stratford Campus

Telephone: 0208 223 4182

Email: w.a.morgan@uel.ac.uk

Contact address:

School of Health, Sport and Bioscience
University of East London
Stratford Campus
Romford Road
London E15 4LZ

Brief biography

I am currently a Principal Lecturer in Toxicology and Biomedical Science, I am also programme leader for the 9 MSc Bioscience masters programmes. My research interests are  varied, I currently supervise two PhD students one working on the role of probiotics and prebiotics in bile acid metabolism and toxicity. The other is on the wound healing properties of certain Nigerian plants. I also have an ongoing project on the toxicity of Amphetamine related compounds (MDMA). Away from laboratory-based research I am involved in a Teaching & Learning project looking at the impact of race, on identity on student performance. For my doctorate I worked in the area of Biochemical Toxicology. In the past I have worked on kidney and liver toxicity, in vitro toxicity testing techniques and developed techniques to be used as alternatives to animals in toxicity testing. My early research was on signal transduction in blood cells and the protein chemistry of auto-antibodies.

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Activities and responsibilities

  • Programme Leader for 9 Bioscience Masters programmes
  • BSc Toxicology programme leader
  • School Equality and Diversity Leader
  • Member of the school Board
  • School Learning & Teaching committee
  • School Research Committee
  • School Research Degrees sub-committee
  • School Quality Standing Committee
  • University Equality & Diversity committee

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Areas of Interest/Summary of Expertise

  • General Toxicology
  • Mechanistic toxicology
  • Toxicity Testing including alternative to animals
  • Kidney and Liver Toxicity
  • Bile acids and cancer
  • MDMA and other amphetamine related Drugs
  • Probiotics and Prebiotics
  • Ethnobotanical agents in would healing
  • Race and ethnicity in student performance

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Teaching: Programmes

  • MSc Toxicology and Biomedical Science
  • BSc Biomedical Science
  • Toxicology
  • Pharmacology
  • Forensic science
  • Biochemistry 

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Teaching: Modules

  • BSM002, BSM003, BSM007, BSM011,BSM012,BS1000, BS100
  • BS1000, BS1100, BS2002, BS2011,BS2018, BS3015, BS3033, BS3034

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Current research and publications

  • The role of dopamine metabolism in the Cytotoxicity of MDMA (3,4-methylenedioxymethamphetamine) and related compounds Yemi Adeeko and Winston A. Morgan . Toxicology 202, 137-138, 2004
  • Does the uncoupling of Mitochondrial Oxidative Phosphorylation by MDMA (3,4-methylenedioxymethamphetamine) and related compounds contribute to hyperthermia? Johnson Afari and Winston A. Morgan; Toxicology 202 139, 2004.
  • Are Bile Acids Involved in the Renal Dysfunction of Obstructive Jaundice? An experimental study in bile duct ligated rats. Balwant Kaler, Winston A. Morgan, Peter H. Bach, Tony Karram, Ibrahaim M. Yousef, and Arieh Bomzon. Renal Failure Volume 26, Issue 5, 507-516, 2004.
  • The use of High Performance Thin-Layer Chromatography to determine the role of membrane lipid composition in bile salt-induced kidney  cell damage Winston A. Morgan, Thanh NK and Yinuo Ding. J. Pharmacological and Toxicological  methods. 57 1,  2008, 70-73.

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Research archive

  • Krishnamurthi S, Morgan WA and Kakkar VV, Extracellular Na+ removal enhances granule secretion in platelet - evidence that Na+/H+ exchanger is inhibitory to secretion induced by some agonist. FEBS. Letts. 250 195-200, 1989.
  • Morgan W, Krishnamurthi S and Kakkar VV, Extracellular Na+ but not Na+/H+ exchange is necessary for agonist-induced arachidonate release in platelets. Thrombosis and Haemostasis 62:(1) 245 1989
  • Krishnamurthi S, Morgan W and Kakkar VV, Intracellular ph elevation via Na+/H+ exchange is inhibitory to platelet granule secretion. Thrombosis and Haemostasis 62: (1) 419, 1989
  • Krishnamurthi S, Morgan WA and Kakkar VV, Intracellular ph elevation via Na+/H+ exchange is an inhibitory signal in thrombin induced dense granule secretion. British Journal of Haematology 73:(3),441 1989.
  • Krishnamurthi S, Morgan WA and Kakkar VV, Extracellular Na+, but  not Na+/H+ exchange, is necessary for receptor-mediated arachidonate release in platelet. Biochem. J. 265: 155-160, 1990.
  •  Krishnamurthi S, Patel Y, Morgan WA Wheeler-Jones CP and Kakkar VV, Na+/H+ exchanger is not necessary for protein kinase C-mediated effects of platelet. FEBS letts. 252:147-152, 1989.
  • Morgan WA, Hartley JA and Cohen GM, Quinone induced DNA single strand breaks in rat hepatocytes and human chronic myelogenous leukaemic K562  cells. Biochem. Phmarmacol 44:215-221, 1992.
  • Ghatineh S, Morgan W, Preece NE and Timbrell JA, Biochemical and nmr spectroscopic study of hydrazine in the isolated rat hepatocyte. Archives of toxicology 66:(9) 660 668, 1992
  • Morgan WA. Kaler B and Bach, The role of oxidative stress in adriamycin-induced selective glomerular toxicity. Abstract: Human and Experimental Toxicology 13:642,1994.
  • Morgan WA. Naphthoquinone-induced DNA breakage in the absence of oxidative stress. Biochem. Soc. Trans. 23:225S 1995.
  • Morgan WA, Pyridine nucleotide hydrolysis and interconversion in rat hepatocytes during oxidative stress. Biochem Pharmacol. 49:1179-1184, 1995.                
  • Morgan WA, DNA single strand breakage in mammalian cells induced by redox cycling quinones in the absence of oxidative stress. J. Biochem. Toxicol. 10:(4) 227-232, 1995
  • Balwant Kaler, Winston A. Morgan, Arieh Bomzon* and Peter H. Bach, The effects of bile salts on freshly isolated rat glomerular and tubular fragments: Human and Experimental Toxicology 14:760,1995
  • Yinuo Ding, Winston A. Morgan and Peter H. Bach, The effects of bile salts on renal cell lines and primary cell cultures. Abstract: Human and Experimental Toxicology 14:761, 1995
  • Kaler B, Morgan WA, Karram T, Bach PH and Bomzom A. Bile acids, obstructive jaundice and renal failure. Hepatology 23:Suppl 1, 249, 1995
  • B. Kaler, Y. Ding, I seefeldt, J. Butcher, W. Morgan, A. Bomzom P.H. Bach, Cytotoxicity of bile acids (BA) in renal fragments and cell lines. Tox. Lett. Supl. 1/78, p.45, 1995.
  • Winston A. Morgan, Balwant kaler and Peter H. Bach, The role of reactive oxygen species in bile acid-mediated cytotoxicity in freshly isolated rat glomerular  and tubular fragments: Human and Experimental Toxicology 15:691, 1996
  • Kaler B, Karram T, Bomzom A Morgan WA and Bach PH . The renal effects of short term chenodeoxycholic acid infusion in rats  Human and Experimental Toxicology 15:690, 1996
  • Kaler B, Karram T, Morgan WA,   Bomzom A and Bach PH. Obstructive jaundice, bile acids, renal injury in vivo and in vitro. Kidney Internationaly 50:1814, 1996
  •  Kaler B, Obatomi DK, Anthonypillai A, Brant S, Morgan WA, and Bach PH. Susceptibility of kidney and liver to chenodeoxycholate using pricision cut rat slices. Journal of Applied Toxicology 15:550, 1996.
  • Winston A. Morgan, Pawan Sharma and Peter H. Bach, The modulation of protein kinase C by Bile salts. Biochem. Soc. Trans. 25:75S, 1997
  • Winston A. Morgan, Balwant kaler and Peter H. Bach, The effect of bile salts on the kinetic properties of enzymes used in the diagnosis of liver and kidney damage. Biochem. Soc. Trans. 25:76S, 1997.
  • Winston A Morgan, Bram Prins and Andries Sj Koster. Relationship betwen acute toxicity of (bis)aziridinyl-benzoquinones and cellular pyridine nucleotides. Arch. Toxicol. 71:(9), 582-587 ,1997
  • Balwant Kaler, Winston Morgan, Arieh Bomzon and Peter H. Bach. The Effects of bile acids on freshly isolated rat glomeruli and proximal tubular fragments. Toxicol. In Vitro. 12:1-7 1997.
  • Winston A. Morgan, Yinuo Ding and Peter H. Bach. The relationship between sodium chloride concentration and bile acid cytotoxicity in cultured kidney cells. Ren. Fail. 20(3),441-450, 1998.
  • Winston A. Morgan, Balwant Kaler and Peter H. Bach, The role of reactive oxygen species in adriamycin and menadione-induced glomerular toxicity. Toxicol. Lett. 94: 209-215,1998.
  • Ratra GS, Morgan W,  Mullervy J, Powell CJ, and Wright MC. Methapyrilene Hepatoxicity is associated with oxidative stress, mitochondrial dysfunction and is prevented by calcium channel blockers. Toxicology 130 (1-2), 79-93 1998.
  • Winston A. Morgan, Balwant Kaler and Peter H. Bach. The role of ursodeoxycholic acid in bile acid-mediated kidney fragment toxicity. Exp. Toxicol Pathol 51: 35-39, 1999
  • Deborah A. Early, Gillian Sturman  S.R. Sooranna and Winston A.. Morgan. Precision-Cut Human Placenta slices as a model for In Vitro Toxicity Testing. Hum. & Exp. Toxicol. 18, 761 1999.

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Other scholarly activities

  • Biochemical Society
  • British Toxicology Society

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