• I completed my PhD entitled ‘Regulation of Gene Expression during T cell development’ in 1996 at what was then the Imperial Cancer Research Fund and is now CRUK.
• I took up a postdoctoral position at the Universidad Autonoma in Madrid for 18 months funded by an EU mobility grant to work on signalling events during T cell development.
• Following this period I worked in the lab of Professor Tessa Crompton at Imperial College London until 2002 as a senior Research Associate working on the role of morphogens, in particular, the  Hedgehog family of morphogens,  in T cell development. The lab then relocated to the Institute of Child Health/UCL in 2002 where I continued to work with Professor Crompton until 2009. The work was funded by the Wellcome Trust and the BBSRC.
• In 2009 I took up the position of Senior Lecturer teaching Immunology here at UEL.

• Module leader for BS3045/BSM005 Immunology
• Module Leader for BS3046/BSM006 Applied Immunology

• Control of Haematopoiesis by morphogens with particular emphasis on T cell and erythroid development.
• Happy to give training on the newly acquired Accuri C6 flow cytometer

• BSc Biomedical Science
• MSc Biomedical Science

BS1000, BS2018, BS2024, BS3015. BS3023, BS3035, BS3045, BS3046, BS3049, BSM005, BSM006, BSM007, BSM009.

       Drakopoulou E*, Outram SV*, Rowbotham NJ, Ross SE, Furmanski AL, Saldana JI, Hager-Theodorides AL, Crompton T (2010). Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development. Cell Cycle. 2010 Oct 15;9(20):4144-52. Epub 2010 Oct 27. *equal contribution.

Hager-Theodorides, AL, Furmanski, AL, Ross,S, Outram, SV, Rowbotham NJ and Crompton, T.
The Gli3 transcription factor, expressed in the thymus stroma, controls thymocyte negative selection via hedgehog dependent and independent mechanisms. J Immunol. 2009 Sep 1;183(5):3023-32. Epub 2009 Aug 10.

Rowbotham, NJ, Hager-Theodorides, AL, Furmanski, AL, Ross, SE, Drakopoulo, E, Outram, SV, Dessens. JT, and Crompton, T. (2009) Shh negatively regulates pre-TCR induced differentiation by a Gli2 dependent mechanism. Blood Mar 9. [Epub ahead of print].

Outram, SV*, Hager-Theodorides, AR*, Shah, DK*, Rowbotham, NJ, Drakopoulou, E, Ross, SE, Lanske, B, Dessens,JT and Crompton, T., (2009) Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation. *equal contribution. Blood. Mar 5;113(10):2217-28.*equal contribution.

Outram, SV *, Gordon, AR*, Hager-Theodorides, AL, Metcalfe, J, Crompton, T, and Kemp, P, (2008) KLF13 influences multiple stages of both B and T cell development. Cell Cycle Volume 7, Issue 13, 2047-55. *equal contribution.

Rowbotham, NJ, Furmanski, AL, Hager-Theodorides, AL, Ross, SE, Drakopoulou, E, Koufaris, C, Outram, SV, Crompton, T. (2008) Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation. Cell Cycle. (7):904-8.

Outram, SV*, Gordon, AR*, Keramatipour, M*, Goddard, CA, Colledge, WH, Metcalfe, JC, Hager-Theodorides, AL, Crompton, T, Kemp, PR. (2008) Splenomegaly and modified erythropoiesis in KLF13-/- mice. J Biol Chem. 283(18):11897-904. 

        Crompton, T, Outram, SV, Hager-Theodorides, AL. (2007) Sonic hedgehog signaling in T-cell development and activation. Nat Rev Immunol. (9):726-35.

Rowbotham, NJ, Hager-Theodorides, AL, Cebecauer, M, Shah, DK, Drakopoulou, E, Dyson, J, Outram, SV, Crompton, T. (2007) Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood. 109(9):3757-66.

Hager-Theodorides, AL, Rowbotham, NJ, Outram, SV, Dessens, JT, Crompton, T. (2007)
Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus. Eur J Immunol. 37(2):487-500.

Hager-Theodorides, A, Dessens, JT, Outram, SV and Crompton, T. (2005) The transcription factor Gli3 is involved in the differentiation of fetal, but not adult, CD4-CD8- Double Negative thymocytes, Blood. 106(4): 1296-304.

Sacedon, R, Nunez, V, Diez, B, Hernandez-lopez, C, Gutierrez-deFrias, C, Outram, SV, Crompton, T, Zapata, A, Cicente, A and Varas, A, (2005) Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis. J Immunol. 174(3):1456-61

Outram, SV, Hager-Theorides, A, Crompton, T. (2005) Hedgehog signalling in T lymphocyte development, ‘’Sonic hedgehog /Glis signalling in development’ Landes Bioscience

Shah, DK, Hager-Theorides, A, Outram, SV, Ross, S, Varas, A, Crompton, T (2004)
Reduced thymocyte development in Sonic Hedgehog Knockout embryos. J. Immunol. 172(4):2296-306.

Sacedon, R, Vicente, A, Hernandez-Lopez, C, Gutierrez, C, Outram, SV, Crompton, T, Varas, A, Zapata, AG. (2003) Hedgehog proteins, expression and function in the thymus. Immunologia vol. 22, 117-26.

Outram, SV*, Hager-Theodorides, AL*, Shah, DK, Sacedon, R, Shrimpton, RE, Vicente, A, Varas, A, Crompton, T (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J Immunol. 169, 5496-504. *equal contribution.

Grimwade, D, Outram, SV, Flora, R, Ings, SJ, Pizzey, AR, Morilla, R, Craddock, CF, Linch, DC, Solomon, E. (2002) The T-Lineage-affiliated CD2 Gene Lies within an Open Chromatin Environment in Acute Promyelocytic Leukemia Cells. Cancer Res. 62(16):4730-5.

Outram, SV, Crompton, T, Merida, I, Varas, A and Martinez-Á, C. (2001) Diacylglycerol kinase  activity is required for survival of CD4+CD8+ thymocytes during development. Immunology. 105 (4):391-8.

Outram, SV, Grimwade, D, Crompton, T, (2001). Repression of CD2 Gene Expression Is Mediated by an AP-2 Related Factor. Biochemical and biophysical research communications, 281, 409-415.

Bugeon, L, Hargreaves, R, Crompton, T, Outram, SV, Rahemtulla, A, Porter, A, Dallman, M, (2001) Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self Mtv-reactive T cells and altered regulation of immune responses Eur. J. Immunol. 31: 118-127.

Outram, SV*, Varas A*, Pepicelli CV, Crompton T (2000) Hedgehog signalling regulates differentiation from double negative to double positive thymocyte. Immunity, 13, 187-197. *equal contribution.

Outram, SV*,Crompton, T*, Buckland, J and Owen, MJ. (1998) Distinct roles for the interleukin 7 receptor ( chain in foetal and adult thymocyte development revealed by analysis of Interleukin 7 receptor alpha deficient mice. Eur. J. Immunol. 28: 1859-1866 *equal contribution.

Crompton, T, Outram, SV, Buckland, J. and Owen, MJ. (1997) A transgenic T cell receptor restores thymocyte differentiation in IL7R chain-deficient mice. Eur J Immunol. 27(1): 100-104.

Outram, SV and Owen, MJ. (1994) The helix-loop-helix containing transcription factor USF activates the promoter of the CD2 gene. J Biol Chem.; 269(42): 26525-26530.

Dorey, EL, Outram, SV, Holder, A, Rohatiner, AZ, Cotter, FE, Deanne, M, Stansfeld, AG, Lister, TA. and Horton, MA. (1989) Assessment of bone marrow infiltration in B-cell non-Hodgkin's lymphoma (NHL). Br J Cancer. 59(5): 772-774.

Outram, SV, Amess, J. and Horton, MA. (1988) Erythromyeloid lineage fidelity is conserved in erythroleukaemia. Leuk Res. 12(8): 651-657.

Rohatiner AZ, Barnett MJ, Arnott S, Plowman N, Cotter F, Adams K, Batten EL, Outram, SV, Amess JA, Horton MA, (1987) Ablative therapy supported by autologous bone marrow transplantation with in vitro treatment of marrow in patients with B-cell malignancy. Hamatol Bluttransfus. 31: 59-61.

Honorary Research Associate at UCL allows the continuation of a strong collaborative link with Professor Tessa Crompton at the Institute of Child Health/UCL

Member of the British Society of Immunology