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Professor Punchard, Neville A.

Contact details

Position: Dean

Location: AE 5.05 Stratford Campus

Telephone: 020 8223 4532

Email: n.punchard@uel.ac.uk

Contact address:

School of Health, Sport and Bioscience
University of East London
Stratford Campus
London E15 4LZ

Brief biography

  • Graduated M.I. Biol. Biochemistry & Immunology, North East Surrey College of Technology.
  • Research Assistant, Inst. of Dermatology, London.
  • Research Assistant, UMDS Dept. of Medicine, St. Thomas' Hospital, London. 
  • Graduated PhD. University of London.
  • Senior Research Fellow, UMDS Dept. of Medicine, St. Thomas' Hospital, London.
  • Honorary Senior Lecturer, UMDS Dept. of Medicine, St. Thomas' Hospital, London.
  • Reader, Faculty of  Science, Technology & Design, University of Luton.
  • Head of Division of Science, University of Bedfordshire

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Activities and responsibilities

Dean of School;

  • Management
  • Leadeship
  • Research & Teaching

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Areas of Interest/Summary of Expertise

  • Established research reputation including over 100 pieces of research output and successful supervision of over 15  research students.
  • Actively involved, including taking lead roles, in the biomedical scientific community. This includes: organisation of national and international conferences; senior and other editorial roles for scientific journals; reviewing of papers and grants from the UK and overseas, and representation/membership of scientific societies and involvement in their activities.
  • Experience in research leadership gained both within a clinical and an academic research environment. Including co-ordinating,  financing, management, and undertaking of research both within and across departments and institutions.
  • Significant management experience gained through holding senior positions, giving extensive team leadership and managerial experience in areas of Health and Science.
  • Over 12 years experience in development, delivery, assessment, quality assurance and critical review of courses at undergraduate and postgraduate level. This includes extensive membership of validation committees for other Departments and Faculties and external examining roles.
  • Wide experience at a senior level within the University. This includes chairing, or representation on, University or School management, research and quality assurance committees, sub committees, interview panels, exam boards, etc.

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Current research and publications

Research

Output: includes over 100 pieces of research output including books, book chapters, peer-reviewed papers and conference presentations (refer to separate list below).

Supervision of research students: previously, over 15 research students,

Research Leadership: Currently; Chair of University Ethics Committee, Member of School Research Committees and, as Dean, proactively lead and direct research in the School. Previously; member of University and Faculty Research and Research Student  committees; Chaired various Faculty/ Departmental Research QA & review committees; managed and led several research groups in several Departments & insitutions; carried our research review and policy development at Departmental and Faculty level; research student recruitment and training as part of lead role in Faculty Graduate School, including organising residential  training sessions and research Days.

RAE: Lead role/ written, or made major input to 3 RAE submissions.

Current research: undertaking biomedical research into cell signalling, free radicals and the immune system in inflammatory conditions, such as inflammatory bowel disease, and during cellular and physiological stress; investigating an in vitro model of granuloma formation.

Previous research interests: I have been involved in other areas of biomedical science research through PhD supervision and other collaboration including inflammation of the skin, pregnancy and alcoholic liver diseases.

Current and previous funding: my research is currently funded through self-funding research students while data is gathered for future applications. Previous funding at been through collaboration, HEFCE RAE income, Biochemical Society, Yakult, NHS, University of London, National Association for Colitis and Crohn's Disease (NACC); Peel Medical Research Trust; Lambeth Endowed Charities; Astra Foundation; G.D. Searle and the Paterson Charitable Trust.

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Research archive

Books & Book Chapters:

  1. "Free radicals- A practical approach". Eds.: Neville A. Punchard & Frank Kelly. In the: 'The Practical Approach Series'.   Series Eds.: D. Rickwood and B.D. Hames. IRL Press, Oxford. 1996.
  2. Introduction to Free Radicals; Chapter 1. In: Free Radicals- A practical approach.  Eds.: Neville A. Punchard & Frank Kelly. In the: 'The Practical Approach Series'.  Series Eds.: D. Rickwood and B.D. Hames IRL Press, Oxford. 1996. pp 1-8
  3. Production of Immortal Human Umbilical Endothelial Cells. Punchard, N.A., Watson, D.W. & Thompson, R.P.H. In: Culture of Immortalised Cells; Book 3 in the “Culture of Specialised Cells” series. Series Ed: R. Ian Freshney. Wiley-Liss. 1996. pp 203-258

Invited Reviews:

  1. Inflammatory Bowel Disease & 5-aminosalicylic acid: ‘Viewpoint' article. British Inflammatory Research Association Newsletter, Dec 1990.
  2. Mechanism of action of 5-aminosalicylic acid. Punchard N.A., Greenfield, S.M. & Thompson R.P.H. Mediators of Inflammation 1992; 1, 151-165.
  3. Nod2 nuclei acid and Proteins (Expert Opinion; published anon). Expert Opinion on Therapeutic Patents, 2003, 13, 111-114
  4. Prostaglandin production and zinc depletion in human pregnancy.  Simmer, K., Punchard, N. A., Murphy, G. & Thompson, R.P.H.  Paediatric Research, 1985; 19, 697-700.
  5. Umbilical arterial prostacyclin production and zinc content in relation to intrauterine growth retardation.  Punchard, N.A., Simmer, K., Murphy, G. & Thompson, R.P.H. Progress in Lipid Research, 1986; 25, 431-2.
  6. Zinc and prostaglandin production in intrauterine growth retardation. Punchard N.A. PhD Thesis. University of  London. 1988.
  7. Inhibition of red cell membrane lipid peroxidation by sulphasalazine and 5-aminosalicylic acid.  Greenfield, S.M., Punchard, N.A. & Thompson, R.P.H.  Gut, 1991; 32, 1156-1159.
  8. Red cell lipid peroxidation and antioxidant enzymes in iron deficiency.  Acharya, J., Punchard, N.A., Taylor, J.A., Thompson R.P.H. & Pearson, T.C.  European Journal of Haematology, 1991; 47, 287-291.
  9. The effects of sulphasalazine and its metabolites on prostaglandin production by human mononuclear cells.  Punchard, N.A., Boswell, D.J., Greenfield, S.M. & Thompson R.P.H.  Biochemical Pharmacology, 1992; 43, 2369-2376.
  10. The effects of 5-aminosalicylic acid and acetyl-5-aminosalicylic acid on lipid peroxidation in erythrocytes and  prostaglandin production by mononuclear cells.  Greenfield, S.M., Boswell, D., Punchard N.A. & Thompson R.P.H. Alimentary Pharmacology and Therapeutics 1992; 6, 671-683.
  11. A randomised controlled study of evening primrose oil and fish oil in ulcerative colitis. Greenfield, S.M., Green, A.T., Teare J.P., Jenkins, A.P., Punchard N.A., Ainley C.C., & Thompson R.P.H. Alimentary Pharmacology and Therapeutics 1993; 7, 159-166.
  12. Expression of adhesion molecules on circulating leucocytes in patients with inflammatory bowel disease. Greenfield, S.M., Hamblin A.H., Punchard N.A. & Thompson R.P.H. Clinical Science 1992; 83, 221-226.
  13. Inhibition of leukocyte adhesion molecule upregulation by tumour necrosis factor : a novel mechanism of action of sulphasalazine. Greenfield, S.M., Hamblin A.H., Shakoor Z.S., Punchard N.A. & Thompson R.P.H. Gut 1993; 34, 252-256.
  14. Effect of Thyroidectomy and adrenalectomy upon liver glutathione and malonaldehyde in response to acute ethanol injection. Teare J.P., Punchard N.A., Greenfield S.M., Marway J.S. Preedy V.R., Peters T.J. & Thompson R.P.H. Free Radical Biology and Medicine 1993; 14; 655-660.
  15. The mode of action of the aminosalicylics in inflammatory bowel disease. Greenfield S.M.,  Punchard N.A.,  & Thompson R.P.H. Alimentary Pharmacology and Therapeutics 1993; 7, 369-383.
  16. An automated spectrophotometric method for determining oxidised and reduced glutathione. Teare J, Punchard, N.A., Powell J.J., Lumb P.J., Mitchell W.D. & Thompson R.P.H. Clin Chem 1993; 38, 686-689.
  17. Resistance of erythrocytes to  lipid peroxidation in alcoholics. Punchard, N.A., Senturk, H, Teare J, & Thompson, R.P.H. Gut 1994 Gut 1994;35, 1753-1756.
  18. Lipid peroxidation in rats chronically fed ethanol.  Teare J.P., Greenfield S.M., Watson D., Punchard N.A., Miller N. , Rice-Evans C.A. and Thompson R.P.H. Gut 1994 35, 1644-1647
  19. A trial of oral zinc supplementation in Psoriasis. Burrows N., Turnbull A.J., Punchard N.A., Thompson R.P.H. & Russell Jones, R. Cutis 1994; 24, 117-118
  20. Proliferative T-cell responses to human papillomavirus type 16 E5 are decreased amongst women with high-grade neoplasia. Gill, D., Bible, J., Biswas, C., Kell, B., Best, J.M., Punchard, N.A. & Cason, J. J. Virology  1998; 79, 1971-1976.
  21. Activation of NFB in Crohn’s Disease. Ellis, R., Goodlad J.R. ,Limb, G.A., Powell, J.P., Thompson, R.P.H. &  Punchard, N.A. Inflammation Research 1998; 47, 440-445.
  22. Inflammatory bowel diseases; something old, something new? (Editorial). Punchard N.A., Current Opinions in Anti- Inflammatory & Immunomodulatory Investigational Drugs 2000 2, 272-4.
  23. Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. Punchard, N.A., Mullins, J. G.Ll. Green, A.T. &.Thompson, R.P.H. Prostaglandins, Leukotrienes & Essential Fatty Acids 2000; 62, 27-33.
  24. Lipopolysaccharide and silica stimulated mononuclear cell prostaglandin production in ulcerative colitis. Punchard, N.A.. Cason, J., Mullins, J., Chander, C., & Thompson, R.P.H. Mediators of Inflammation 2000: 9, 189-191.
  25. Glucorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Kagoshima, M., Wilcke, T., Ito, K., Tsaprouni, L., Barnes, P.J., Punchard, N.A. & Adcock, I.
    European Journal of Pharmacology, 2001: 429, 327-34.
  26. Nod2 and Crohn's disease: the cause, or contributor to Crohn's disease? (Overview). Punchard N.A., Current Opinions in Anti- Inflammatory & Immunomodulatory Investigational Drugs 2001: 2, 1378-81
  27. Triamcinolone Acetonide and Dexamethasome supress TNF-a-Induced histone H4 acetylation on lysine residues 8 & 12 in mononuclear cells. Tsaprouni, L., Ito, K., Punchard, N.A. & Adcock, I. Ann. N. Acad. Sci. 2002: 973, 1-4.
  28. Selective Binding of nucleotide probes by eosinophlilic cationic protein during in situ hybridisation. Ellis, R., Ashwood, P., Powell, J.P., Taylor, P.D., Poulson, R., Thompson, R.P.H & Punchard, N.A. The Histochemical Journal, 2002, 34, 153-160.
  29. Nod2 nuclei acid and Proteins (Invited Expert Opinion; published anon). Expert Opinion on Therapeutic Patents, 2003, 13, 111-114.
  30. Editorial: The Journal of Inflammation. Punchard, N.A. , Whelan, C.J., Adcock, I. Journal of Inflammation 2004, 1: 1.
  31. Report of resistance to the neonicotinoid insecticide imidacloprid in Trialeurodes vaporariorum (Hemiptera: Aleyrodidae). Gorman, K., Devine G., Bennison, J., Coussons, P.  Punchard, N., & Denholm, I. (Pest Management Science 2007 (In press;  E-version published).
  32. Dietary Calcium Modulates Mucosal Caspase Expression and Disease Activity in the DSS Model of Murine Colitis.  Powell1, J.J., Pele1, L.C. Thoree1, V., Mustafa1, F., He1, S., Tsaprouni, L., Punchard, N.A.,  Thompson, R.P.H & Evans, S. M. Journal of  Nutrition 2007 (In press).
  33. Suppression of LPS and TNF-induced IL-8 expression by glucocorticoids involves changes in acetylation of the IL-8 promoter. Tsaprouni, L. Ito, K., Adcock, I., & Punchard, N.A.  Clinical & experimental Immunology 2007; (In press)
  34. The Role of JAK2 and PKB in LPS stimulated NF-kappaB activation in RAW 264.7 cells. Jones, E., Adcock, I., Paul, C., & Punchard, N.A.  J. Inflamm. (In press)

Invited Talks:

  • Role of reactive oxygen species in inflammatory bowel disease. 14th British Inflammation Research Association Meeting on the Cellular and Molecular aspects of Inflammatory Bowel Disease, St Thomas' Hospital, London;  November 25, 1992.
  • Reactive oxygen metabolites in gut inflammation. Tissue damage and healing in the human intestine: molecular and cellular mediators. Royal Society of Medicine-Section on Clinical Immunology and Allergy, London. March 8th, 1993.
  • Immortalisation of human umbilical vein endothelial cells. Vectorial transport in cultured epithelial and endothelial cells. European Tissue Culture Society Workshop. University of Newcastle upon Tyne,  April 19th, 1993.
  • Immortalisation of endothelial cells with Oncogenes. At: "Transformation and immortalisation of mammalian cells". European Tissue Culture Society (UK Branch), University of Sussex. April 6th-8th, 1994
  • NFB in Crohn's Disease. Receptor Signalling in Inflammatory cells. British Inflammation Research Association, London; University of East London, April 23rd, 1998.
  • NFB in Inflammatory Bowel Disease. Pfizer, Kent. Nov 5/6th, 1998.
    Functional Role of immune-cell signalling in the intestine. Nutrition Department, King’s College London. May 30th, 2001.

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Other scholarly activities

  1. Committees:
  • British Inflammation Research Association (BIRAs): Academic Committee Member (from 1993); Secretary (1994 to 2002); Newsletter Editor (from 1994-1998); Vice-Chair & Web Site Creator and Manager (from 2001); Institute of Biology Representative (from 1998).
  • International Association of Inflammation Societies (IAIS): Steering committee for the bi-annual meeting, "Inflammation' 95” (from 1993-1995) and Inflammation 2001. On IAIS committee (from 1995).
  • British Society for Immunology Nutritional Immunology Group  (2000+)
  • Biochemical Society's Professional and Educational Committee Representative for the University of Luton on Local London section (1997-1999).
  1. Meetings Organised & Chaired

    International:

    • Chaired workshop on Inflammatory Bowel Diseases at Inflammation' 2001, Edinburgh, Sept. 2001. (Attendance of 500).
    • IAIS bi-annual meeting, Inflammation' 95, Brighton Sept. 1995. (Attendance of 800). Organised and chaired workshop on: Skin and Gastrointestinal Inflammation.

    National:

    • Signalling in inflammatory & immune cells: cell surface to nucleus. Annual congress of the British Society for Immunology (BSI), Harrogate, 2004.
    • Nutrition and Inflammation. 9th Annual congress of the BSI, Harrogate, 2001. 
    • The Endothelium and Inflammation. 7th Annual congress of the BSI joint with the British Society for Allergy and Clinical Immunology Harrogate, Nov. 30th- 3rd, 1999.
    • Chemokines (joint BIRAs session at BSI Annual Congress, Harrogate 1998).
    • Stroke and Neurodegenerative Diseases, St Thomas’ Hospital, Dec. 1st, 1995.
    • Cellular and Molecular Aspects of Inflammatory Bowel Disease, St Thomas’ Hospital, Nov. 25th, 1992
  2. Editorial roles:
  • Editor in Chief for Journal of  Inflammation; Editorial Board of; Journal of Occupational Medicine & Toxicology; Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs (1999+); International Drugs database (ID) Research Alerts (1997-8).
  1. Grant Reviewer for:
  • Broad Medical Research Program, California, USA (2000)+; Lottery Community Funds (2001+); Telethon Foundation (Italian); Anglian and Oxford Regional Health Authority; St Bartholomew’s Hospital Joint Research Board, & The Special Trustees of St Thomas’ Hospital.
  1. Journal Reviewer for:
  • European Journal of Clinical Nutrition (Nature group); Inflammation Research; Lupus; Endocrinology and Metabolism; Current Drugs ID Alerts; British Journal of Pharmacology; Drugs, Gut; Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs; Nicotine & Tobacco Research.

Membership of Societies:

  • Heads of University Centres for Biomedical Science
  • Fellow of the Institute of Biomedical Science
  • British Inflammatory Research Association as Academic Committee Member (Vice-Chair; Institute of Biology Representative)
  • Fellow of the Higher Education Academy (Biochemical Society; British Society for Immunology.

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